Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice

Transplantation of induced pluripotent stem cell-derived cardiac tissue constructs is a promising regenerative treatment for cardiac failure: however, its tumourigenic potential is concerning. We hypothesised that the tumourigenic potential may be eliminated by the host immune response after allogen...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19464, Article 19464
Hauptverfasser:	Kawamura, Ai, Miyagawa, Shigeru, Fukushima, Satsuki, Kawamura, Takuji, Kashiyama, Noriyuki, Ito, Emiko, Watabe, Tadashi, Masuda, Shigeo, Toda, Koichi, Hatazawa, Jun, Morii, Eiichi, Sawa, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/107 13/109 13/31 13/51 14/5 14/63 59/57 59/78 64/60 692/308/2171 692/4028/67/1679 96/21 Animal models Animals Biopsy CD4 antigen CD8 antigen Cell Line Cell Transformation, Neoplastic Fluorodeoxyglucose F18 Gene Order Genetic Vectors - genetics Graft rejection Graft Rejection - immunology Heart diseases Heart transplantation Humanities and Social Sciences Immune response Immunocompromised Host Immunosuppressive Agents - administration & dosage Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Injection Lymphocytes T Male Mice Mice, Transgenic Models, Animal multidisciplinary Myocytes, Cardiac - cytology Myocytes, Cardiac - pathology Pluripotency Positron emission tomography Science Stem Cell Transplantation - adverse effects Stem cells Syngeneic grafts T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tacrolimus Tacrolimus - administration & dosage Teratocarcinoma Teratocarcinoma - diagnosis Teratocarcinoma - etiology Teratocarcinoma - pathology Transplantation Transplantation, Homologous Tumors
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