Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

Manipulating the function of neurons and circuits that translate electrical and chemical signals into behavior represents a major challenges in neuroscience. In addition to optogenetic methods using light-activatable channels, pharmacogenetic methods with ligand induced modulation of cell signaling...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19293-19293, Article 19293
Hauptverfasser:	Auffenberg, Eva, Jurik, Angela, Mattusch, Corinna, Stoffel, Rainer, Genewsky, Andreas, Namendorf, Christian, Schmid, Roland M., Rammes, Gerhard, Biel, Martin, Uhr, Manfred, Moosmang, Sven, Michalakis, Stylianos, Wotjak, Carsten T., Thoeringer, Christoph K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 631/443 64 64/60 96/44 Animals Behavior, Animal - drug effects Biodegradation Cell Line Circuits Ectopic expression Excitability Humanities and Social Sciences Humans Memory - drug effects Mice Morpholines - pharmacology multidisciplinary Nervous system Neurons - drug effects Neurons - physiology Neurosciences Potassium Potassium channels (inwardly-rectifying) Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Interaction Domains and Motifs - genetics Protein Stability - drug effects Proteins Science Tacrolimus Binding Protein 1A - genetics Tacrolimus Binding Protein 1A - metabolism
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