Identification of miR-15b as a transformation-related factor in mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with a poor prognosis. It is characterized by the t(11;14)(q13;q32) translocation, resulting in overexpression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), with a proportion o...
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| Veröffentlicht in: | International journal of oncology 2016-02, Vol.48 (2), p.485-492 |
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| creator | ARAKAWA, FUMIKO KIMURA, YOSHIZO YOSHIDA, NORIAKI MIYOSHI, HIROAKI DOI, ATUSHI YASUDA, KAORI NAKAJIMA, KAZUTAKA KIYASU, JUNICHI NIINO, DAISUKE SUGITA, YASUO TASHIRO, KOSUKE KUHARA, SATORU SETO, MASAO OHSHIMA, KOICHI |
| description | Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with a poor prognosis. It is characterized by the t(11;14)(q13;q32) translocation, resulting in overexpression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), with a proportion of cMCL progressing to develop into aMCL. miRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies. Although several genetic alterations have been implicated in the transformation of cMCL to aMCL, the involvement of miRNAs in transformation is not known. In an effort to identify the miRNAs related to the transformation of MCL, miRNA microarray analyses were used for cMCL and aMCL cases. These analyses demonstrated significant differences in the expression of seven microRNAs based on a t-test (p-value |
| doi_str_mv | 10.3892/ijo.2015.3295 |
| format | Article |
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It is characterized by the t(11;14)(q13;q32) translocation, resulting in overexpression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), with a proportion of cMCL progressing to develop into aMCL. miRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies. Although several genetic alterations have been implicated in the transformation of cMCL to aMCL, the involvement of miRNAs in transformation is not known. In an effort to identify the miRNAs related to the transformation of MCL, miRNA microarray analyses were used for cMCL and aMCL cases. These analyses demonstrated significant differences in the expression of seven microRNAs based on a t-test (p-value <0.05); miR-15b was greatly upregulated in aMCL. Locked nucleic acid in situ hybridization showed increased staining of miR-15b in formalin-fixed paraffin-embedded sections of aMCL. These results correlated well with the microRNA microarray analysis. Although the molecular functions of miR-15b are largely unknown, it has been found to be associated with the cell cycle and apoptosis. However, the physiological significance of increased miR-15b in MCL is still unknown. Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the transformation of cMCL to aMCL.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2015.3295</identifier><identifier>PMID: 26676972</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Aged ; Aged, 80 and over ; Apoptosis - genetics ; Biomarkers, Tumor - genetics ; Cell cycle ; Cell Cycle - genetics ; Classification ; Cyclin D1 - genetics ; Development and progression ; Female ; Gene expression ; Gene Expression Profiling - methods ; Gene Expression Regulation, Neoplastic - genetics ; Genetic aspects ; Health aspects ; Humans ; Identification and classification ; in situ hybridization ; laser microdissection ; Lasers ; Lymphoma ; Lymphoma, B-Cell - genetics ; Lymphoma, Mantle-Cell - genetics ; Male ; Mantle cell lymphoma ; Microarray Analysis - methods ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; miR-15b ; miRNA microarray ; Morphology ; Prognosis ; Transformation, Genetic - genetics ; Up-Regulation - genetics</subject><ispartof>International journal of oncology, 2016-02, Vol.48 (2), p.485-492</ispartof><rights>Copyright: © Arakawa et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Arakawa et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-52861b81e782867db6ecc6c37e63ba4c259f89dc6b13eb3736ee2680b92c6cc93</citedby><cites>FETCH-LOGICAL-c611t-52861b81e782867db6ecc6c37e63ba4c259f89dc6b13eb3736ee2680b92c6cc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,5570,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26676972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARAKAWA, FUMIKO</creatorcontrib><creatorcontrib>KIMURA, YOSHIZO</creatorcontrib><creatorcontrib>YOSHIDA, NORIAKI</creatorcontrib><creatorcontrib>MIYOSHI, HIROAKI</creatorcontrib><creatorcontrib>DOI, ATUSHI</creatorcontrib><creatorcontrib>YASUDA, KAORI</creatorcontrib><creatorcontrib>NAKAJIMA, KAZUTAKA</creatorcontrib><creatorcontrib>KIYASU, JUNICHI</creatorcontrib><creatorcontrib>NIINO, DAISUKE</creatorcontrib><creatorcontrib>SUGITA, YASUO</creatorcontrib><creatorcontrib>TASHIRO, KOSUKE</creatorcontrib><creatorcontrib>KUHARA, SATORU</creatorcontrib><creatorcontrib>SETO, MASAO</creatorcontrib><creatorcontrib>OHSHIMA, KOICHI</creatorcontrib><title>Identification of miR-15b as a transformation-related factor in mantle cell lymphoma</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with a poor prognosis. It is characterized by the t(11;14)(q13;q32) translocation, resulting in overexpression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), with a proportion of cMCL progressing to develop into aMCL. miRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies. Although several genetic alterations have been implicated in the transformation of cMCL to aMCL, the involvement of miRNAs in transformation is not known. In an effort to identify the miRNAs related to the transformation of MCL, miRNA microarray analyses were used for cMCL and aMCL cases. These analyses demonstrated significant differences in the expression of seven microRNAs based on a t-test (p-value <0.05); miR-15b was greatly upregulated in aMCL. Locked nucleic acid in situ hybridization showed increased staining of miR-15b in formalin-fixed paraffin-embedded sections of aMCL. These results correlated well with the microRNA microarray analysis. Although the molecular functions of miR-15b are largely unknown, it has been found to be associated with the cell cycle and apoptosis. However, the physiological significance of increased miR-15b in MCL is still unknown. Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the transformation of cMCL to aMCL.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis - genetics</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Classification</subject><subject>Cyclin D1 - genetics</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>in situ hybridization</subject><subject>laser microdissection</subject><subject>Lasers</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, Mantle-Cell - genetics</subject><subject>Male</subject><subject>Mantle cell lymphoma</subject><subject>Microarray Analysis - methods</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miR-15b</subject><subject>miRNA microarray</subject><subject>Morphology</subject><subject>Prognosis</subject><subject>Transformation, Genetic - genetics</subject><subject>Up-Regulation - genetics</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1rGzEQhpfS0qRpj70WQaE9ydHHSlpdCiEkbSAQCOlZaLWzsYxWcqV1IP--cpwaG4oOGjTPvMyM3qb5TMmCd5qd-1VaMELFgjMt3jSnVGmKWcv42xoTqrFsuT5pPpSyIoQJQej75oRJqaRW7LR5uBkgzn70zs4-RZRGNPl7TEWPbEEWzdnGMqY8vaRxhmBnGNBo3Zwy8hFNNs4BkIMQUHie1ss02Y_Nu9GGAp9e77Pm9_XVw-UvfHv38-by4hY7SemMBesk7TsKqquRGnoJzknHFUje29YxocdOD072lEPPFZcATHak16xiTvOz5sdOd73pJxhcnSTbYNbZTzY_m2S9Oc5EvzSP6cm0iolW0Crw9VUgpz8bKLNZpU2OtWdDNWecdIofUI82gPFxTFXMTb44c9G2gkulNKnU4j9UPQNM3qUIo6_vRwXfDgqWYMO8LClstosuxyDegS6nUjKM-wkpMVsTmGoCszWB2Zqg8l8O17Kn__16Bb7vgLK2cfBDKnumKuG2w4Rh0naC_wXyMrjB</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>ARAKAWA, FUMIKO</creator><creator>KIMURA, YOSHIZO</creator><creator>YOSHIDA, NORIAKI</creator><creator>MIYOSHI, HIROAKI</creator><creator>DOI, ATUSHI</creator><creator>YASUDA, KAORI</creator><creator>NAKAJIMA, KAZUTAKA</creator><creator>KIYASU, JUNICHI</creator><creator>NIINO, DAISUKE</creator><creator>SUGITA, YASUO</creator><creator>TASHIRO, KOSUKE</creator><creator>KUHARA, SATORU</creator><creator>SETO, MASAO</creator><creator>OHSHIMA, KOICHI</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Identification of miR-15b as a transformation-related factor in mantle cell lymphoma</title><author>ARAKAWA, FUMIKO ; KIMURA, YOSHIZO ; YOSHIDA, NORIAKI ; MIYOSHI, HIROAKI ; DOI, ATUSHI ; YASUDA, KAORI ; NAKAJIMA, KAZUTAKA ; KIYASU, JUNICHI ; NIINO, DAISUKE ; SUGITA, YASUO ; TASHIRO, KOSUKE ; KUHARA, SATORU ; SETO, MASAO ; OHSHIMA, KOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-52861b81e782867db6ecc6c37e63ba4c259f89dc6b13eb3736ee2680b92c6cc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis - genetics</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cell cycle</topic><topic>Cell Cycle - genetics</topic><topic>Classification</topic><topic>Cyclin D1 - genetics</topic><topic>Development and progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>in situ hybridization</topic><topic>laser microdissection</topic><topic>Lasers</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, Mantle-Cell - genetics</topic><topic>Male</topic><topic>Mantle cell lymphoma</topic><topic>Microarray Analysis - methods</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miR-15b</topic><topic>miRNA microarray</topic><topic>Morphology</topic><topic>Prognosis</topic><topic>Transformation, Genetic - genetics</topic><topic>Up-Regulation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARAKAWA, FUMIKO</creatorcontrib><creatorcontrib>KIMURA, YOSHIZO</creatorcontrib><creatorcontrib>YOSHIDA, NORIAKI</creatorcontrib><creatorcontrib>MIYOSHI, HIROAKI</creatorcontrib><creatorcontrib>DOI, ATUSHI</creatorcontrib><creatorcontrib>YASUDA, KAORI</creatorcontrib><creatorcontrib>NAKAJIMA, KAZUTAKA</creatorcontrib><creatorcontrib>KIYASU, JUNICHI</creatorcontrib><creatorcontrib>NIINO, DAISUKE</creatorcontrib><creatorcontrib>SUGITA, YASUO</creatorcontrib><creatorcontrib>TASHIRO, KOSUKE</creatorcontrib><creatorcontrib>KUHARA, SATORU</creatorcontrib><creatorcontrib>SETO, MASAO</creatorcontrib><creatorcontrib>OHSHIMA, KOICHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARAKAWA, FUMIKO</au><au>KIMURA, YOSHIZO</au><au>YOSHIDA, NORIAKI</au><au>MIYOSHI, HIROAKI</au><au>DOI, ATUSHI</au><au>YASUDA, KAORI</au><au>NAKAJIMA, KAZUTAKA</au><au>KIYASU, JUNICHI</au><au>NIINO, DAISUKE</au><au>SUGITA, YASUO</au><au>TASHIRO, KOSUKE</au><au>KUHARA, SATORU</au><au>SETO, MASAO</au><au>OHSHIMA, KOICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of miR-15b as a transformation-related factor in mantle cell lymphoma</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>48</volume><issue>2</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with a poor prognosis. It is characterized by the t(11;14)(q13;q32) translocation, resulting in overexpression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), with a proportion of cMCL progressing to develop into aMCL. miRNAs are currently considered to be important regulators for cell behavior and are deregulated in many malignancies. Although several genetic alterations have been implicated in the transformation of cMCL to aMCL, the involvement of miRNAs in transformation is not known. In an effort to identify the miRNAs related to the transformation of MCL, miRNA microarray analyses were used for cMCL and aMCL cases. These analyses demonstrated significant differences in the expression of seven microRNAs based on a t-test (p-value <0.05); miR-15b was greatly upregulated in aMCL. Locked nucleic acid in situ hybridization showed increased staining of miR-15b in formalin-fixed paraffin-embedded sections of aMCL. These results correlated well with the microRNA microarray analysis. Although the molecular functions of miR-15b are largely unknown, it has been found to be associated with the cell cycle and apoptosis. However, the physiological significance of increased miR-15b in MCL is still unknown. Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the transformation of cMCL to aMCL.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26676972</pmid><doi>10.3892/ijo.2015.3295</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Apoptosis - genetics Biomarkers, Tumor - genetics Cell cycle Cell Cycle - genetics Classification Cyclin D1 - genetics Development and progression Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Genetic aspects Health aspects Humans Identification and classification in situ hybridization laser microdissection Lasers Lymphoma Lymphoma, B-Cell - genetics Lymphoma, Mantle-Cell - genetics Male Mantle cell lymphoma Microarray Analysis - methods MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miR-15b miRNA microarray Morphology Prognosis Transformation, Genetic - genetics Up-Regulation - genetics |
| title | Identification of miR-15b as a transformation-related factor in mantle cell lymphoma |
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