Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling

The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic hypothalamic neurogenesis has been observed, but the role of radial glia in generating these new neurons is unclear. We have used inducib...

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Veröffentlicht in:	Development (Cambridge) 2016-01, Vol.143 (1), p.45-53
Hauptverfasser:	Duncan, Robert N, Xie, Yuanyuan, McPherson, Adam D, Taibi, Andrew V, Bonkowsky, Joshua L, Douglass, Adam D, Dorsky, Richard I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified beta Catenin - genetics Cell Proliferation Cell Self Renewal - physiology Danio rerio Ependymoglial Cells - cytology Hypothalamus - cytology Hypothalamus - embryology Immunohistochemistry In Situ Hybridization Intercellular Signaling Peptides and Proteins - metabolism Neural Stem Cells - cytology Neurogenesis - physiology Stem Cells and Regeneration Wnt Proteins - genetics Wnt Signaling Pathway - genetics Zebrafish - embryology Zebrafish Proteins - metabolism
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