Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Copper is a transition metal that plays critical roles in many life processes. Controlling the cellular concentration and trafficking of copper offers a route to disrupt these processes. Here we report small molecules that inhibit the human copper-trafficking proteins Atox1 and CCS, and so provide a...

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Veröffentlicht in:	Nature chemistry 2015-12, Vol.7 (12), p.968-979
Hauptverfasser:	Wang, Jing, Luo, Cheng, Shan, Changliang, You, Qiancheng, Lu, Junyan, Elf, Shannon, Zhou, Yu, Wen, Yi, Vinkenborg, Jan L., Fan, Jun, Kang, Heebum, Lin, Ruiting, Han, Dali, Xie, Yuxin, Karpus, Jason, Chen, Shijie, Ouyang, Shisheng, Luan, Chihao, Zhang, Naixia, Ding, Hong, Merkx, Maarten, Liu, Hong, Chen, Jing, Jiang, Hualiang, He, Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 639/638/45/49/1141 639/638/92/507 639/638/92/555 639/638/92/556 Amino Acid Sequence Analytical Chemistry Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology ATP Biochemistry Cancer Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemistry Chemistry/Food Science Copper Copper - metabolism Drug Discovery Gene Knockdown Techniques Humans Inorganic Chemistry Kinases Metallochaperones - antagonists & inhibitors Metallochaperones - chemistry Metallochaperones - genetics Metallochaperones - metabolism Mice Molecular Chaperones - antagonists & inhibitors Molecular Chaperones - chemistry Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular Sequence Data Neoplasms - metabolism Organic Chemistry Oxidative stress Oxidative Stress - drug effects Physical Chemistry Proteins Sequence Alignment Xenograft Model Antitumor Assays
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