Immunotherapy and tumor microenvironment

•The TME can dampen or enhance the efficacy of immunotherapy.•Immunotherapy targets both the TME and tumor cells.•Manipulating the TME can improve current immunotherapies. Recent exciting progress in cancer immunotherapy has ushered in a new era of cancer treatment. Immunotherapy can elicit unpreced...

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Veröffentlicht in:	Cancer letters 2016-01, Vol.370 (1), p.85-90
Hauptverfasser:	Tang, Haidong, Qiao, Jian, Fu, Yang-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation B7-H1 Antigen - antagonists & inhibitors Cancer Cancer therapies CAR T-cell therapy Checkpoint blockade Chemokine Chemokine CCL21 - analysis Clinical trials CTLA-4 Antigen - antagonists & inhibitors Cytokine Cytokines Cytotoxicity Hematology, Oncology and Palliative Medicine Humans Immune system Immunoglobulins Immunotherapy Ligands Lymphocytes Neoplasms - immunology Neoplasms - therapy Radiation therapy Receptors, Antigen, T-Cell - genetics Receptors, Pattern Recognition - physiology Response rates Studies T cell receptors T-Lymphocytes - immunology Tumor Microenvironment Tumor Necrosis Factor Ligand Superfamily Member 14 - physiology Tumor-infiltrating immune cells Tumors
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