Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma
Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor ef...
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| Veröffentlicht in: | Journal of controlled release 2016-02, Vol.223, p.75-84 |
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| creator | Cheng, Yu Muroski, Megan E. Petit, Dorothée C.M.C. Mansell, Rhodri Vemulkar, Tarun Morshed, Ramin A. Han, Yu Balyasnikova, Irina V. Horbinski, Craig M. Huang, Xinlei Zhang, Lingjiao Cowburn, Russell P. Lesniak, Maciej S. |
| description | Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.
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| doi_str_mv | 10.1016/j.jconrel.2015.12.028 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2015.12.028</identifier><identifier>PMID: 26708022</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Brain - metabolism ; Brain - pathology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cell Line, Tumor ; Glioma - drug therapy ; Glioma - metabolism ; Glioma - pathology ; Humans ; Magnetic field ; Magnetic Fields ; Magnetic particles ; Male ; Malignant glioma ; Mechanical destruction ; Mice ; Mice, Nude ; Microscopy, Electron, Transmission ; Nanoparticles - administration & dosage ; Nanoparticles - therapeutic use ; Tissue Distribution ; Tumor Burden</subject><ispartof>Journal of controlled release, 2016-02, Vol.223, p.75-84</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-99b0bde0400fa7ffe92cb00ad7f22cf9171a50d5084e5ed9e4f98e9597bc771d3</citedby><cites>FETCH-LOGICAL-c537t-99b0bde0400fa7ffe92cb00ad7f22cf9171a50d5084e5ed9e4f98e9597bc771d3</cites><orcidid>0000-0002-6026-0731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2015.12.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26708022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Yu</creatorcontrib><creatorcontrib>Muroski, Megan E.</creatorcontrib><creatorcontrib>Petit, Dorothée C.M.C.</creatorcontrib><creatorcontrib>Mansell, Rhodri</creatorcontrib><creatorcontrib>Vemulkar, Tarun</creatorcontrib><creatorcontrib>Morshed, Ramin A.</creatorcontrib><creatorcontrib>Han, Yu</creatorcontrib><creatorcontrib>Balyasnikova, Irina V.</creatorcontrib><creatorcontrib>Horbinski, Craig M.</creatorcontrib><creatorcontrib>Huang, Xinlei</creatorcontrib><creatorcontrib>Zhang, Lingjiao</creatorcontrib><creatorcontrib>Cowburn, Russell P.</creatorcontrib><creatorcontrib>Lesniak, Maciej S.</creatorcontrib><title>Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.
[Display omitted]</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Glioma - drug therapy</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Magnetic field</subject><subject>Magnetic Fields</subject><subject>Magnetic particles</subject><subject>Male</subject><subject>Malignant glioma</subject><subject>Mechanical destruction</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Microscopy, Electron, Transmission</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - therapeutic use</subject><subject>Tissue Distribution</subject><subject>Tumor Burden</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCTwD5yCXBduJ1fAGhii-pUqUKzpZjj1OvHHuxk1X597japYVTT3Pw88545kHoDSUtJXT7ftfuTIoZQssI5S1lLWHDM7Shg-iaXkr-HG0qNzTdlstz9LKUHSGEd714gc7ZVpCBMLZBdzdp0YuPE571FGHxBjsPwWIf7WrA4lSMD6EiKeLkHqm9zrUEKNilXGl88IeEZzC3OnqjA7ZQlryax2DwU9RxwVPwadav0JnTocDrU71AP798_nH5rbm6_vr98tNVY3gnlkbKkYwWSE-I08I5kMyMhGgrHGPGSSqo5sRyMvTAwUronRxAcilGIwS13QX6cOy7X8cZrIG4ZB3UPvtZ598qaa_-f4n-Vk3poHrB-p7z2uDdqUFOv9a6lJp9MVBvEiGtRVGxHfjQCSIryo-oyamUDO5hDCXq3praqZM1dW9NUaaqtZp7--8fH1J_NVXg4xGAeqmDh6yqFYjVj89gFmWTf2LEH8dhsDE</recordid><startdate>20160210</startdate><enddate>20160210</enddate><creator>Cheng, Yu</creator><creator>Muroski, Megan E.</creator><creator>Petit, Dorothée C.M.C.</creator><creator>Mansell, Rhodri</creator><creator>Vemulkar, Tarun</creator><creator>Morshed, Ramin A.</creator><creator>Han, Yu</creator><creator>Balyasnikova, Irina V.</creator><creator>Horbinski, Craig M.</creator><creator>Huang, Xinlei</creator><creator>Zhang, Lingjiao</creator><creator>Cowburn, Russell P.</creator><creator>Lesniak, Maciej S.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6026-0731</orcidid></search><sort><creationdate>20160210</creationdate><title>Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma</title><author>Cheng, Yu ; Muroski, Megan E. ; Petit, Dorothée C.M.C. ; Mansell, Rhodri ; Vemulkar, Tarun ; Morshed, Ramin A. ; Han, Yu ; Balyasnikova, Irina V. ; Horbinski, Craig M. ; Huang, Xinlei ; Zhang, Lingjiao ; Cowburn, Russell P. ; Lesniak, Maciej S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-99b0bde0400fa7ffe92cb00ad7f22cf9171a50d5084e5ed9e4f98e9597bc771d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Glioma - drug therapy</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Magnetic field</topic><topic>Magnetic Fields</topic><topic>Magnetic particles</topic><topic>Male</topic><topic>Malignant glioma</topic><topic>Mechanical destruction</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Microscopy, Electron, Transmission</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - therapeutic use</topic><topic>Tissue Distribution</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Yu</creatorcontrib><creatorcontrib>Muroski, Megan E.</creatorcontrib><creatorcontrib>Petit, Dorothée C.M.C.</creatorcontrib><creatorcontrib>Mansell, Rhodri</creatorcontrib><creatorcontrib>Vemulkar, Tarun</creatorcontrib><creatorcontrib>Morshed, Ramin A.</creatorcontrib><creatorcontrib>Han, Yu</creatorcontrib><creatorcontrib>Balyasnikova, Irina V.</creatorcontrib><creatorcontrib>Horbinski, Craig M.</creatorcontrib><creatorcontrib>Huang, Xinlei</creatorcontrib><creatorcontrib>Zhang, Lingjiao</creatorcontrib><creatorcontrib>Cowburn, Russell P.</creatorcontrib><creatorcontrib>Lesniak, Maciej S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Yu</au><au>Muroski, Megan E.</au><au>Petit, Dorothée C.M.C.</au><au>Mansell, Rhodri</au><au>Vemulkar, Tarun</au><au>Morshed, Ramin A.</au><au>Han, Yu</au><au>Balyasnikova, Irina V.</au><au>Horbinski, Craig M.</au><au>Huang, Xinlei</au><au>Zhang, Lingjiao</au><au>Cowburn, Russell P.</au><au>Lesniak, Maciej S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2016-02-10</date><risdate>2016</risdate><volume>223</volume><spage>75</spage><epage>84</epage><pages>75-84</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers.
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| ispartof | Journal of controlled release, 2016-02, Vol.223, p.75-84 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Apoptosis Brain - metabolism Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Glioma - drug therapy Glioma - metabolism Glioma - pathology Humans Magnetic field Magnetic Fields Magnetic particles Male Malignant glioma Mechanical destruction Mice Mice, Nude Microscopy, Electron, Transmission Nanoparticles - administration & dosage Nanoparticles - therapeutic use Tissue Distribution Tumor Burden |
| title | Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma |
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