Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

The aims of the present study were to determine the relationship between bone destruction and bone formation in the delayed-type hypersensitivity arthritis (DTHA) model and to evaluate the effect of receptor activator of nuclear factor κB ligand (RANKL) blockade on severity of arthritis, bone destru...

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Veröffentlicht in:	Arthritis research & therapy 2016-01, Vol.18 (28), p.28-28, Article 28
Hauptverfasser:	Atkinson, Sara Marie, Bleil, Janine, Maier, René, Kühl, Anja A, Thorn, Mette, Serikawa, Kyle, Fox, Brian, Kruse, Kim, Haase, Claus, Skov, Søren, Nansen, Anneline, Syrbe, Uta
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic reaction Allergy Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Cathepsins Collagen Enzyme-linked immunosorbent assay Enzymes Female Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Joints - drug effects Joints - metabolism Joints - pathology Messenger RNA Mice Mice, Inbred C57BL Monoclonal antibodies Osteogenesis - drug effects Osteogenesis - physiology Phosphatases RANK Ligand - antagonists & inhibitors RANK Ligand - metabolism Rats
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