Trichosanthin suppresses the proliferation of glioma cells by inhibiting LGR5 expression and the Wnt/β-catenin signaling pathway

Studies have indicated that trichosanthin (TCS), a bioactive protein extracted and purified from the tuberous root of Trichosanthes kirilowii (a well-known traditional Chinese medicinal plant), produces antitumor effects on various types of cancer cells. However, the effects of TCS on glioma cells a...

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Veröffentlicht in:	Oncology reports 2015-12, Vol.34 (6), p.2845-2852
Hauptverfasser:	MIAO, JUNJIE, JIANG, YILIN, WANG, DONGLIANG, ZHOU, JINGRU, FAN, CUNGANG, JIAO, FENG, LIU, BO, ZHANG, JUN, WANG, YANGSHUO, ZHANG, QINGJUN
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Brain cancer Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival Cellular signal transduction Chemotherapy Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - chemistry Flow cytometry Gene Expression Regulation, Neoplastic - drug effects Glioma Glioma - drug therapy Glioma - genetics Glioma - pathology Gliomas Health aspects Humans LGR5 Materia medica, Vegetable Medicinal plants Morphology Phosphorylation Plant extracts Proteins Radiation therapy Receptors, G-Protein-Coupled - biosynthesis Receptors, G-Protein-Coupled - genetics Studies Trichosanthes - chemistry trichosanthin Trichosanthin - administration & dosage Trichosanthin - chemistry Tumors Wnt Signaling Pathway - drug effects Wnt/β-catenin signaling
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