Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer. Herein, we report our newly synthesiz...

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Veröffentlicht in:	BMC cancer 2016-01, Vol.16 (26), p.35-35, Article 35
Hauptverfasser:	Park, Chi Hoon, Cho, Sung Yun, Ha, Jae Du, Jung, Heejung, Kim, Hyung Rae, Lee, Chong Ock, Jang, In-Young, Chae, Chong Hak, Lee, Heung Kyoung, Choi, Sang Un
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemical synthesis Cancer Cell Line, Tumor Cell Proliferation - drug effects Development and progression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Humans Mice Oncogenes Physiological aspects Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - chemical synthesis Proto-Oncogene Proteins c-met - biosynthesis Proto-Oncogene Proteins c-met - genetics Pyrazines - administration & dosage Pyrazines - chemical synthesis Signal Transduction - drug effects Stomach cancer Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - pathology Triazoles - administration & dosage Triazoles - chemical synthesis Xenograft Model Antitumor Assays
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