The effect of 5-fluorouracil/leucovorin chemotherapy on CpG methylation, or the confounding role of leukocyte heterogeneity: An illustration

Blood-based epigenome-wide association studies that aim at comparing CpG methylation between colorectal cancer (CRC) patients and controls can lead to the discovery of diagnostic or prognostic biomarkers. Numerous confounders can lead to spurious associations. We aimed to see if 5-fluorouracil (5-FU...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2015-12, Vol.106 (6), p.340-347
Hauptverfasser:	Lemire, Mathieu, Zaidi, Syed H.E., Zanke, Brent W., Gallinger, Steven, Hudson, Thomas J., Cleary, Sean P.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemotherapy Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics CpG Islands - genetics DNA Methylation - drug effects Epigenesis, Genetic - drug effects Epigenomics - methods Female Fluorouracil - administration & dosage Heterogeneity Humans Leucovorin - administration & dosage Leukocyte Count Leukocytes Leukocytes - drug effects Leukocytes - metabolism Linear Models Male Methylation Middle Aged Smoking
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!