The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin

Prothrombin (FII) is activated to α-thrombin (IIa) by prothrombinase. Prothrombinase is composed of a catalytic subunit, factor Xa (fXa), and a regulatory subunit, factor Va (fVa), assembled on a membrane surface in the presence of divalent metal ions. We constructed, expressed, and purified several...

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Veröffentlicht in:	The Journal of biological chemistry 2016-01, Vol.291 (4), p.1565-1581
Hauptverfasser:	Wiencek, Joesph R., Hirbawi, Jamila, Yee, Vivien C., Kalafatis, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Amino Acid Motifs Amino Acid Sequence blood coagulation factor factor v Factor Va - genetics Factor Va - metabolism factor Xa Factor Xa - genetics Factor Xa - metabolism Glutamine - genetics Glutamine - metabolism Humans Leucine - genetics Leucine - metabolism Molecular Sequence Data mutation Protein C - genetics Protein C - metabolism Protein Processing, Post-Translational Protein Structure and Folding prothrombin Prothrombin - chemistry Prothrombin - genetics Prothrombin - metabolism prothrombinase thrombin Thromboplastin - genetics Thromboplastin - metabolism thrombosis
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