Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

Chinese hamster ovary (CHO) cells are the preferred host cell line for manufacturing a variety of complex biotherapeutic drugs including monoclonal antibodies. We performed a proteomics and bioinformatics analysis on the spent medium from adherent CHO cells. Supernatant from CHO-K1 culture was colle...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of proteome research 2015-11, Vol.14 (11), p.4687-4703
Hauptverfasser:	Kumar, Amit, Baycin-Hizal, Deniz, Wolozny, Daniel, Pedersen, Lasse Ebdrup, Lewis, Nathan E, Heffner, Kelley, Chaerkady, Raghothama, Cole, Robert N, Shiloach, Joseph, Zhang, Hui, Bowen, Michael A, Betenbaugh, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - genetics Biological Transport Cell Proliferation CHO Cells - cytology CHO Cells - secretion Chromatography, Liquid Computational Biology - methods Cricetulus Culture Media, Conditioned - chemistry Cytoplasm - chemistry Cytoskeleton - chemistry Gene Expression Molecular Sequence Annotation Protein Interaction Mapping Protein Sorting Signals - genetics Proteolysis Proteome - genetics Proteome - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Secretory Pathway - genetics Tandem Mass Spectrometry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!