NRF2 regulates serine biosynthesis in non–small cell lung cancer

Lewis Cantley and colleagues report an integrated metabolic and transcriptomic study of non–small cell lung cancer (NSCLC) cell lines. They show that the activity of the serine/glycine biosynthetic pathway in NSCLC is highly heterogeneous and is regulated by NRF2 and that elevated expression of gene...

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Veröffentlicht in:	Nature genetics 2015-12, Vol.47 (12), p.1475-1481
Hauptverfasser:	DeNicola, Gina M, Chen, Pei-Hsuan, Mullarky, Edouard, Sudderth, Jessica A, Hu, Zeping, Wu, David, Tang, Hao, Xie, Yang, Asara, John M, Huffman, Kenneth E, Wistuba, Ignacio I, Minna, John D, DeBerardinis, Ralph J, Cantley, Lewis C
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38 45 631/208/199 631/45/320 692/699/67/1612/1350 82/58 96 Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Agriculture Animal Genetics and Genomics Animals Apoptosis Bioinformatics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedicine Biosynthesis Blotting, Western Cancer Research Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Cell metabolism Cell Proliferation Development and progression Enzymes Experiments Gene expression Gene Expression Regulation, Neoplastic Gene Function Genetic aspects Genetic transcription Health aspects Human Genetics Humans Immunoenzyme Techniques Labeling letter Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Mass spectrometry Medical research Metabolism Metabolites Mice NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Properties Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA polymerase RNA, Messenger - genetics RNA, Small Interfering - genetics Scientific imaging Serine - biosynthesis Transcription factors Tumor Cells, Cultured Tumorigenesis Xenograft Model Antitumor Assays
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