Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

Nearly a century ago, Otto Warburg made the ground-breaking observation that cancer cells, unlike normal cells, prefer a seemingly inefficient mechanism of glucose metabolism: aerobic glycolysis, a phenomenon now referred to as the Warburg effect. The finding that rapidly proliferating cancer cells...

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Veröffentlicht in:	World journal of surgical oncology 2016-01, Vol.14 (1), p.15-15, Article 15
Hauptverfasser:	Li, Chunxia, Zhang, Guifeng, Zhao, Lei, Ma, Zhijun, Chen, Hongbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biomarkers, Tumor - metabolism Cancer cells Cell Proliferation - drug effects Cell Proliferation - physiology Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - metabolism Glucose metabolism Glutamine - metabolism Glycolysis - drug effects Glycolysis - physiology Humans Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Proto-Oncogene Proteins c-bcl-2 - metabolism Review Synthesis
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