Teaching Medical Students to Help Patients Quit Smoking: Outcomes of a 10-School Randomized Controlled Trial

Background Early in medical education, physicians must develop competencies needed for tobacco dependence treatment. Objective To assess the effect of a multi-modal tobacco dependence treatment curriculum on medical students’ counseling skills. Design A group-randomized controlled trial (2010–2014)...

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Veröffentlicht in:Journal of general internal medicine : JGIM 2016-02, Vol.31 (2), p.172-181
Hauptverfasser: Ockene, Judith K., Hayes, Rashelle B., Churchill, Linda C., Crawford, Sybil L., Jolicoeur, Denise G., Murray, David M., Shoben, Abigail B., David, Sean P., Ferguson, Kristi J., Huggett, Kathryn N., Adams, Michael, Okuliar, Catherine A., Gross, Robin L., Bass, Pat F., Greenberg, Ruth B., Leone, Frank T., Okuyemi, Kola S., Rudy, David W., Waugh, Jonathan B., Geller, Alan C.
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container_end_page 181
container_issue 2
container_start_page 172
container_title Journal of general internal medicine : JGIM
container_volume 31
creator Ockene, Judith K.
Hayes, Rashelle B.
Churchill, Linda C.
Crawford, Sybil L.
Jolicoeur, Denise G.
Murray, David M.
Shoben, Abigail B.
David, Sean P.
Ferguson, Kristi J.
Huggett, Kathryn N.
Adams, Michael
Okuliar, Catherine A.
Gross, Robin L.
Bass, Pat F.
Greenberg, Ruth B.
Leone, Frank T.
Okuyemi, Kola S.
Rudy, David W.
Waugh, Jonathan B.
Geller, Alan C.
description Background Early in medical education, physicians must develop competencies needed for tobacco dependence treatment. Objective To assess the effect of a multi-modal tobacco dependence treatment curriculum on medical students’ counseling skills. Design A group-randomized controlled trial (2010–2014) included ten U.S. medical schools that were randomized to receive either multi-modal tobacco treatment education (MME) or traditional tobacco treatment education (TE). Setting/Participants Students from the classes of 2012 and 2014 at ten medical schools participated. Students from the class of 2012 ( N  = 1345) completed objective structured clinical examinations (OSCEs), and 50 % ( N  = 660) were randomly selected for pre-intervention evaluation. A total of 72.9 % of eligible students ( N  = 1096) from the class of 2014 completed an OSCE and 69.7 % ( N  = 1047) completed pre and post surveys. Interventions The MME included a Web-based course, a role-play classroom demonstration, and a clerkship booster session. Clerkship preceptors in MME schools participated in an academic detailing module and were encouraged to be role models for third-year students. Measurements The primary outcome was student tobacco treatment skills using the 5As measured by an objective structured clinical examination (OSCE) scored on a 33-item behavior checklist. Secondary outcomes were student self-reported skills for performing 5As and pharmacotherapy counseling. Results Although the difference was not statistically significant, MME students completed more tobacco counseling behaviors on the OSCE checklist (mean 8.7 [SE 0.6] vs. mean 8.0 [SE 0.6], p  = 0.52) than TE students. Several of the individual Assist and Arrange items were significantly more likely to have been completed by MME students, including suggesting behavioral strategies (11.8 % vs. 4.5 %, p  
doi_str_mv 10.1007/s11606-015-3508-y
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Objective To assess the effect of a multi-modal tobacco dependence treatment curriculum on medical students’ counseling skills. Design A group-randomized controlled trial (2010–2014) included ten U.S. medical schools that were randomized to receive either multi-modal tobacco treatment education (MME) or traditional tobacco treatment education (TE). Setting/Participants Students from the classes of 2012 and 2014 at ten medical schools participated. Students from the class of 2012 ( N  = 1345) completed objective structured clinical examinations (OSCEs), and 50 % ( N  = 660) were randomly selected for pre-intervention evaluation. A total of 72.9 % of eligible students ( N  = 1096) from the class of 2014 completed an OSCE and 69.7 % ( N  = 1047) completed pre and post surveys. Interventions The MME included a Web-based course, a role-play classroom demonstration, and a clerkship booster session. Clerkship preceptors in MME schools participated in an academic detailing module and were encouraged to be role models for third-year students. Measurements The primary outcome was student tobacco treatment skills using the 5As measured by an objective structured clinical examination (OSCE) scored on a 33-item behavior checklist. Secondary outcomes were student self-reported skills for performing 5As and pharmacotherapy counseling. Results Although the difference was not statistically significant, MME students completed more tobacco counseling behaviors on the OSCE checklist (mean 8.7 [SE 0.6] vs. mean 8.0 [SE 0.6], p  = 0.52) than TE students. Several of the individual Assist and Arrange items were significantly more likely to have been completed by MME students, including suggesting behavioral strategies (11.8 % vs. 4.5 %, p  &lt; 0.001) and providing information regarding quitline (21.0 % vs. 3.8 %, p  &lt; 0.001). MME students reported higher self-efficacy for Assist, Arrange, and Pharmacotherapy counseling items ( ps  ≤0.05). Limitations Inclusion of only ten schools limits generalizability. Conclusions Subsequent interventions should incorporate lessons learned from this first randomized controlled trial of a multi-modal longitudinal tobacco treatment curriculum in multiple U.S. medical schools. NIH Trial Registry Number: NCT01905618</description><identifier>ISSN: 0884-8734</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-015-3508-y</identifier><identifier>PMID: 26391030</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Clinical Clerkship ; Clinical Competence ; Clinical trials ; Computer-Assisted Instruction - methods ; Counseling ; Counseling - education ; Curricula ; Curriculum ; Drug therapy ; Education ; Education, Medical, Undergraduate - methods ; Humans ; Internal Medicine ; Medical personnel ; Medical schools ; Medical students ; Medicine ; Medicine &amp; Public Health ; Original Research ; Outcome Assessment (Health Care) ; Pharmacology ; Physicians ; Randomization ; Schools ; Self Efficacy ; Skills ; Smoking ; Smoking Cessation - methods ; Statistical analysis ; Students ; Students, Medical ; Tobacco ; Tobacco Use Disorder - rehabilitation ; United States</subject><ispartof>Journal of general internal medicine : JGIM, 2016-02, Vol.31 (2), p.172-181</ispartof><rights>Society of General Internal Medicine 2015</rights><rights>Journal of General Internal Medicine is a copyright of Springer, (2015). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-a0e1fe5ee62af998a9f3179948a7571be75e6f8461d91fea84753721f6b8cbb53</citedby><cites>FETCH-LOGICAL-c540t-a0e1fe5ee62af998a9f3179948a7571be75e6f8461d91fea84753721f6b8cbb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720645/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720645/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,41493,42562,51324,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26391030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ockene, Judith K.</creatorcontrib><creatorcontrib>Hayes, Rashelle B.</creatorcontrib><creatorcontrib>Churchill, Linda C.</creatorcontrib><creatorcontrib>Crawford, Sybil L.</creatorcontrib><creatorcontrib>Jolicoeur, Denise G.</creatorcontrib><creatorcontrib>Murray, David M.</creatorcontrib><creatorcontrib>Shoben, Abigail B.</creatorcontrib><creatorcontrib>David, Sean P.</creatorcontrib><creatorcontrib>Ferguson, Kristi J.</creatorcontrib><creatorcontrib>Huggett, Kathryn N.</creatorcontrib><creatorcontrib>Adams, Michael</creatorcontrib><creatorcontrib>Okuliar, Catherine A.</creatorcontrib><creatorcontrib>Gross, Robin L.</creatorcontrib><creatorcontrib>Bass, Pat F.</creatorcontrib><creatorcontrib>Greenberg, Ruth B.</creatorcontrib><creatorcontrib>Leone, Frank T.</creatorcontrib><creatorcontrib>Okuyemi, Kola S.</creatorcontrib><creatorcontrib>Rudy, David W.</creatorcontrib><creatorcontrib>Waugh, Jonathan B.</creatorcontrib><creatorcontrib>Geller, Alan C.</creatorcontrib><title>Teaching Medical Students to Help Patients Quit Smoking: Outcomes of a 10-School Randomized Controlled Trial</title><title>Journal of general internal medicine : JGIM</title><addtitle>J GEN INTERN MED</addtitle><addtitle>J Gen Intern Med</addtitle><description>Background Early in medical education, physicians must develop competencies needed for tobacco dependence treatment. Objective To assess the effect of a multi-modal tobacco dependence treatment curriculum on medical students’ counseling skills. Design A group-randomized controlled trial (2010–2014) included ten U.S. medical schools that were randomized to receive either multi-modal tobacco treatment education (MME) or traditional tobacco treatment education (TE). Setting/Participants Students from the classes of 2012 and 2014 at ten medical schools participated. Students from the class of 2012 ( N  = 1345) completed objective structured clinical examinations (OSCEs), and 50 % ( N  = 660) were randomly selected for pre-intervention evaluation. A total of 72.9 % of eligible students ( N  = 1096) from the class of 2014 completed an OSCE and 69.7 % ( N  = 1047) completed pre and post surveys. Interventions The MME included a Web-based course, a role-play classroom demonstration, and a clerkship booster session. Clerkship preceptors in MME schools participated in an academic detailing module and were encouraged to be role models for third-year students. Measurements The primary outcome was student tobacco treatment skills using the 5As measured by an objective structured clinical examination (OSCE) scored on a 33-item behavior checklist. Secondary outcomes were student self-reported skills for performing 5As and pharmacotherapy counseling. Results Although the difference was not statistically significant, MME students completed more tobacco counseling behaviors on the OSCE checklist (mean 8.7 [SE 0.6] vs. mean 8.0 [SE 0.6], p  = 0.52) than TE students. Several of the individual Assist and Arrange items were significantly more likely to have been completed by MME students, including suggesting behavioral strategies (11.8 % vs. 4.5 %, p  &lt; 0.001) and providing information regarding quitline (21.0 % vs. 3.8 %, p  &lt; 0.001). MME students reported higher self-efficacy for Assist, Arrange, and Pharmacotherapy counseling items ( ps  ≤0.05). Limitations Inclusion of only ten schools limits generalizability. Conclusions Subsequent interventions should incorporate lessons learned from this first randomized controlled trial of a multi-modal longitudinal tobacco treatment curriculum in multiple U.S. medical schools. NIH Trial Registry Number: NCT01905618</description><subject>Clinical Clerkship</subject><subject>Clinical Competence</subject><subject>Clinical trials</subject><subject>Computer-Assisted Instruction - methods</subject><subject>Counseling</subject><subject>Counseling - education</subject><subject>Curricula</subject><subject>Curriculum</subject><subject>Drug therapy</subject><subject>Education</subject><subject>Education, Medical, Undergraduate - methods</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical personnel</subject><subject>Medical schools</subject><subject>Medical students</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Research</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pharmacology</subject><subject>Physicians</subject><subject>Randomization</subject><subject>Schools</subject><subject>Self Efficacy</subject><subject>Skills</subject><subject>Smoking</subject><subject>Smoking Cessation - methods</subject><subject>Statistical analysis</subject><subject>Students</subject><subject>Students, Medical</subject><subject>Tobacco</subject><subject>Tobacco Use Disorder - rehabilitation</subject><subject>United States</subject><issn>0884-8734</issn><issn>1525-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU9vEzEQxS1ERUPhA3BBljgbbK__ckBCEVCkVgUSzpZ315u4eNep7UUKnx6HtKUcOI0185s3T34AvCD4NcFYvsmECCwQJhw1HCu0fwQWhFOOCNPyMVhgpRhSsmGn4GnO1xiThlL1BJxS0WiCG7wAYe1st_XTBl663nc2wFWZezeVDEuE5y7s4Bdb_J_G19kXuBrjj4q_hVdz6eLoMowDtJBgtOq2MQb4zU59HP0v18NlnEqKIdTnOnkbnoGTwYbsnt_WM_D944f18hxdXH36vHx_gTrOcEEWOzI47pygdtBaWT00RGrNlJVcktZJ7sSgmCC9rqBVTPJGUjKIVnVty5sz8O6ou5vb0fVddZ9sMLvkR5v2Jlpv_p1Mfms28adhkmLBDgKvbgVSvJldLuY6zmmqng09_KISmpJKkSPVpZhzcsP9BYLNISBzDMjUgMwhILOvOy8fWrvfuEukAvQI5DqaNi79Pf1_1d8pPJ0M</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Ockene, Judith K.</creator><creator>Hayes, Rashelle B.</creator><creator>Churchill, Linda C.</creator><creator>Crawford, Sybil L.</creator><creator>Jolicoeur, Denise G.</creator><creator>Murray, David M.</creator><creator>Shoben, Abigail B.</creator><creator>David, Sean P.</creator><creator>Ferguson, Kristi J.</creator><creator>Huggett, Kathryn N.</creator><creator>Adams, Michael</creator><creator>Okuliar, Catherine A.</creator><creator>Gross, Robin L.</creator><creator>Bass, Pat F.</creator><creator>Greenberg, Ruth B.</creator><creator>Leone, Frank T.</creator><creator>Okuyemi, Kola S.</creator><creator>Rudy, David W.</creator><creator>Waugh, Jonathan B.</creator><creator>Geller, Alan C.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Teaching Medical Students to Help Patients Quit Smoking: Outcomes of a 10-School Randomized Controlled Trial</title><author>Ockene, Judith K. ; Hayes, Rashelle B. ; Churchill, Linda C. ; Crawford, Sybil L. ; Jolicoeur, Denise G. ; Murray, David M. ; Shoben, Abigail B. ; David, Sean P. ; Ferguson, Kristi J. ; Huggett, Kathryn N. ; Adams, Michael ; Okuliar, Catherine A. ; Gross, Robin L. ; Bass, Pat F. ; Greenberg, Ruth B. ; Leone, Frank T. ; Okuyemi, Kola S. ; Rudy, David W. ; Waugh, Jonathan B. ; Geller, Alan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-a0e1fe5ee62af998a9f3179948a7571be75e6f8461d91fea84753721f6b8cbb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Clinical Clerkship</topic><topic>Clinical Competence</topic><topic>Clinical trials</topic><topic>Computer-Assisted Instruction - methods</topic><topic>Counseling</topic><topic>Counseling - education</topic><topic>Curricula</topic><topic>Curriculum</topic><topic>Drug therapy</topic><topic>Education</topic><topic>Education, Medical, Undergraduate - methods</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical personnel</topic><topic>Medical schools</topic><topic>Medical students</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Original Research</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pharmacology</topic><topic>Physicians</topic><topic>Randomization</topic><topic>Schools</topic><topic>Self Efficacy</topic><topic>Skills</topic><topic>Smoking</topic><topic>Smoking Cessation - methods</topic><topic>Statistical analysis</topic><topic>Students</topic><topic>Students, Medical</topic><topic>Tobacco</topic><topic>Tobacco Use Disorder - rehabilitation</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ockene, Judith K.</creatorcontrib><creatorcontrib>Hayes, Rashelle B.</creatorcontrib><creatorcontrib>Churchill, Linda C.</creatorcontrib><creatorcontrib>Crawford, Sybil L.</creatorcontrib><creatorcontrib>Jolicoeur, Denise G.</creatorcontrib><creatorcontrib>Murray, David M.</creatorcontrib><creatorcontrib>Shoben, Abigail B.</creatorcontrib><creatorcontrib>David, Sean P.</creatorcontrib><creatorcontrib>Ferguson, Kristi J.</creatorcontrib><creatorcontrib>Huggett, Kathryn N.</creatorcontrib><creatorcontrib>Adams, Michael</creatorcontrib><creatorcontrib>Okuliar, Catherine A.</creatorcontrib><creatorcontrib>Gross, Robin L.</creatorcontrib><creatorcontrib>Bass, Pat F.</creatorcontrib><creatorcontrib>Greenberg, Ruth B.</creatorcontrib><creatorcontrib>Leone, Frank T.</creatorcontrib><creatorcontrib>Okuyemi, Kola S.</creatorcontrib><creatorcontrib>Rudy, David W.</creatorcontrib><creatorcontrib>Waugh, Jonathan B.</creatorcontrib><creatorcontrib>Geller, Alan C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing &amp; 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Objective To assess the effect of a multi-modal tobacco dependence treatment curriculum on medical students’ counseling skills. Design A group-randomized controlled trial (2010–2014) included ten U.S. medical schools that were randomized to receive either multi-modal tobacco treatment education (MME) or traditional tobacco treatment education (TE). Setting/Participants Students from the classes of 2012 and 2014 at ten medical schools participated. Students from the class of 2012 ( N  = 1345) completed objective structured clinical examinations (OSCEs), and 50 % ( N  = 660) were randomly selected for pre-intervention evaluation. A total of 72.9 % of eligible students ( N  = 1096) from the class of 2014 completed an OSCE and 69.7 % ( N  = 1047) completed pre and post surveys. Interventions The MME included a Web-based course, a role-play classroom demonstration, and a clerkship booster session. Clerkship preceptors in MME schools participated in an academic detailing module and were encouraged to be role models for third-year students. Measurements The primary outcome was student tobacco treatment skills using the 5As measured by an objective structured clinical examination (OSCE) scored on a 33-item behavior checklist. Secondary outcomes were student self-reported skills for performing 5As and pharmacotherapy counseling. Results Although the difference was not statistically significant, MME students completed more tobacco counseling behaviors on the OSCE checklist (mean 8.7 [SE 0.6] vs. mean 8.0 [SE 0.6], p  = 0.52) than TE students. Several of the individual Assist and Arrange items were significantly more likely to have been completed by MME students, including suggesting behavioral strategies (11.8 % vs. 4.5 %, p  &lt; 0.001) and providing information regarding quitline (21.0 % vs. 3.8 %, p  &lt; 0.001). MME students reported higher self-efficacy for Assist, Arrange, and Pharmacotherapy counseling items ( ps  ≤0.05). Limitations Inclusion of only ten schools limits generalizability. Conclusions Subsequent interventions should incorporate lessons learned from this first randomized controlled trial of a multi-modal longitudinal tobacco treatment curriculum in multiple U.S. medical schools. NIH Trial Registry Number: NCT01905618</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26391030</pmid><doi>10.1007/s11606-015-3508-y</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4720645
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central; Alma/SFX Local Collection
subjects Clinical Clerkship
Clinical Competence
Clinical trials
Computer-Assisted Instruction - methods
Counseling
Counseling - education
Curricula
Curriculum
Drug therapy
Education
Education, Medical, Undergraduate - methods
Humans
Internal Medicine
Medical personnel
Medical schools
Medical students
Medicine
Medicine & Public Health
Original Research
Outcome Assessment (Health Care)
Pharmacology
Physicians
Randomization
Schools
Self Efficacy
Skills
Smoking
Smoking Cessation - methods
Statistical analysis
Students
Students, Medical
Tobacco
Tobacco Use Disorder - rehabilitation
United States
title Teaching Medical Students to Help Patients Quit Smoking: Outcomes of a 10-School Randomized Controlled Trial
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T05%3A08%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Teaching%20Medical%20Students%20to%20Help%20Patients%20Quit%20Smoking:%20Outcomes%20of%20a%2010-School%20Randomized%20Controlled%20Trial&rft.jtitle=Journal%20of%20general%20internal%20medicine%20:%20JGIM&rft.au=Ockene,%20Judith%20K.&rft.date=2016-02-01&rft.volume=31&rft.issue=2&rft.spage=172&rft.epage=181&rft.pages=172-181&rft.issn=0884-8734&rft.eissn=1525-1497&rft_id=info:doi/10.1007/s11606-015-3508-y&rft_dat=%3Cproquest_pubme%3E2001386921%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2001386921&rft_id=info:pmid/26391030&rfr_iscdi=true