Functional interplay between ganglioside GM1 and cross‐linking galectin‐1 induces axon‐like neuritogenesis via integrin‐based signaling and TRPC5‐dependent Ca2+ influx

Axon‐like neuritogenesis in neuroblastoma (NG108‐15) cells and primary cerebellar granular neurons is furthered by the presence of ganglioside GM1. We describe here that galectin‐1 (Gal‐1), a homobivalent endogenous lectin, is an effector by cross‐linking the ganglioside and its associated glycoprot...

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Veröffentlicht in:	Journal of neurochemistry 2016-02, Vol.136 (3), p.550-563
Hauptverfasser:	Wu, Gusheng, Lu, Zi‐Hua, André, Sabine, Gabius, Hans‐Joachim, Ledeen, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn axon growth Axons - physiology Benzamides - pharmacokinetics Ca2+ level Calcium - metabolism Cells, Cultured Cerebellum - cytology Enzyme Inhibitors - pharmacology G(M1) Ganglioside - genetics G(M1) Ganglioside - metabolism Galectin 1 - genetics Galectin 1 - metabolism ganglioside Gene Expression Regulation - genetics integrin Integrins - genetics Integrins - metabolism lectin Mice Mice, Inbred C57BL Mice, Knockout Neurochemistry neuron Original ORIGINAL ARTICLES Protein Binding - drug effects Protein Binding - genetics Rats RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - genetics Temperature TRPC Cation Channels - genetics TRPC Cation Channels - metabolism Tyrosine - analogs & derivatives Tyrosine - pharmacokinetics
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