A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation

A fundamental goal of genomics is to identify the complete set of expressed proteins. Automated annotation strategies rely on assumptions about protein-coding sequences (CDSs), e.g., they are conserved, do not overlap, and exceed a minimum length. However, an increasing number of newly discovered pr...

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Veröffentlicht in:	Molecular cell 2015-12, Vol.60 (5), p.816-827
Hauptverfasser:	Fields, Alexander P., Rodriguez, Edwin H., Jovanovic, Marko, Stern-Ginossar, Noam, Haas, Brian J., Mertins, Philipp, Raychowdhury, Raktima, Hacohen, Nir, Carr, Steven A., Ingolia, Nicholas T., Regev, Aviv, Weissman, Jonathan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cells, Cultured Conserved Sequence dendritic cells Dendritic Cells - drug effects fibroblasts genomics Humans Lipopolysaccharides - pharmacology Mice Open Reading Frames protein synthesis proteins Proteome - metabolism Proteomics - methods Regression Analysis ribosomes Ribosomes - metabolism
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