Persistent Simian Immunodeficiency Virus Infection Drives Differentiation, Aberrant Accumulation, and Latent Infection of Germinal Center Follicular T Helper Cells

CD4(+) follicular T helper (Tfh) cells play a prominent role in humoral immune responses, but the mechanisms of their accumulation and infection in AIDS remain unclear. Here we found that germinal center (GC) Tfh cells, defined here as CXCR5(+) PD-1(HIGH) CD4(+) T cells, do not express the HIV corec...

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Veröffentlicht in:	Journal of virology 2016-02, Vol.90 (3), p.1578-1587
Hauptverfasser:	Xu, Huanbin, Wang, Xiaolei, Malam, Naomi, Aye, Pyone P, Alvarez, Xavier, Lackner, Andrew A, Veazey, Ronald S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - chemistry CD4-Positive T-Lymphocytes - virology Cell Differentiation Germinal Center - virology Human immunodeficiency virus Immunophenotyping Macaca mulatta Pathogenesis and Immunity Programmed Cell Death 1 Receptor - analysis Receptors, CXCR5 - analysis Simian Acquired Immunodeficiency Syndrome - pathology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - growth & development Simian Immunodeficiency Virus - physiology T-Lymphocyte Subsets - chemistry T-Lymphocyte Subsets - virology T-Lymphocytes, Helper-Inducer - chemistry T-Lymphocytes, Helper-Inducer - virology Virus Latency
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