Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities

We have previously reported the construction of a murine leukemia virus-based replication-competent gammaretrovirus (SL3-AP) capable of utilizing the human G protein-coupled receptor APJ (hAPJ) as its entry receptor and its natural receptor, the murine Xpr1 receptor, with equal affinities. The apeli...

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Veröffentlicht in:	Journal of virology 2016-02, Vol.90 (3), p.1647-1656
Hauptverfasser:	Friis, Kristina Pagh, Iturrioz, Xavier, Thomsen, Jonas, Alvear-Perez, Rodrigo, Bahrami, Shervin, Llorens-Cortes, Catherine, Pedersen, Finn Skou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apelin Receptors Cell Line Chemical Sciences Directed Molecular Evolution Gammaretrovirus - genetics Gammaretrovirus - physiology Genomic Instability Human immunodeficiency virus 1 Humans Life Sciences Receptors, G-Protein-Coupled - metabolism Receptors, Virus - metabolism Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Viral Tropism Virus Internalization Virus-Cell Interactions
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