Sox6 suppression induces RA-dependent apoptosis mediated by BMP-4 expression during neuronal differentiation in P19 cells

Sox6 is a transcription factor that induces neuronal differentiation in P19 cells; its suppression not only inhibits neuronal differentiation but also induces retinoic acid (RA)-dependent apoptosis of P19 cells. In the present study, we found that Sox6 suppression-induced apoptosis was mediated by a...

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Veröffentlicht in:	Molecular and cellular biochemistry 2016-01, Vol.412 (1-2), p.49-57
Hauptverfasser:	Hamada-Kanazawa, Michiko, Ogawa, Daisuke, Takano, Masaoki, Miyake, Masaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology B cells Biochemistry Biomedical and Life Sciences Bone Morphogenetic Protein 4 - metabolism Bone morphogenetic proteins Cardiology Caspases - metabolism Cell Differentiation Cell Line Enzyme Activation Enzymes Life Sciences Medical Biochemistry Mice Mitochondrial DNA Mortality Neurons Neutralization Oncology Protein expression SOXD Transcription Factors - physiology Tretinoin - pharmacology
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