Ascorbic acid prevents VEGF-induced increases in endothelial barrier permeability

Vascular endothelial growth factor (VEGF) increases endothelial barrier permeability, an effect that may contribute to macular edema in diabetic retinopathy. Since vitamin C, or ascorbic acid, can tighten the endothelial permeability barrier, we examined whether it could prevent the increase in perm...

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Veröffentlicht in:	Molecular and cellular biochemistry 2016-01, Vol.412 (1-2), p.73-79
Hauptverfasser:	Ulker, Esad, Parker, William H., Raj, Amita, Qu, Zhi-chao, May, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Ascorbic Acid - pharmacology Biochemistry Biomedical and Life Sciences Cardiology Cellular biology Diabetic retinopathy Edema Endothelium Endothelium, Vascular - physiology Enzymes Human Umbilical Vein Endothelial Cells Humans Life Sciences Medical Biochemistry Nitric oxide Nitric Oxide - physiology Oncology Oxidative stress Permeability Prevention Protein expression Superoxides Vascular endothelial growth factor Vascular Endothelial Growth Factor A - physiology Vitamin C
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