Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity

Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdom...

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Veröffentlicht in:	Experimental cell research 2016-01, Vol.340 (1), p.43-52
Hauptverfasser:	Hettmer, Simone, Lin, Michael M., Tchessalova, Daria, Tortorici, Sara J., Castiglioni, Alessandra, Desai, Tushar, Mao, Junhao, McMahon, Andrew P., Wagers, Amy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACTIN Alleles Animals BROMIDES CARBOXYLIC ACIDS CATTLE CELL DIFFERENTIATION Cell Proliferation Cellular biology CHAIN REACTIONS CHICKENS Differentiation ESTROGENS Flow Cytometry FLUORESCENCE GROWTH FACTORS Hedgehog Proteins - metabolism Hedgehog signaling Intratumoral cellular heterogeneity IODIDES MICE Mice, Inbred C57BL Muscle, Skeletal - metabolism Muscle, Skeletal - pathology MUSCLES Musculoskeletal system NEOPLASMS Neoplasms, Muscle Tissue - metabolism Neoplasms, Muscle Tissue - pathology PHENOTYPE PLANT GROWTH POLYMERASE CHAIN REACTION POLYMERASES RECEPTORS RNA SALTS Skeletal muscle TAMOXIFEN Tumors ZINC
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