Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics

Antibodies are currently the fastest‐growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half‐life. They have been conjugated to toxic payloads, PEGs, or radioisotope...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-01, Vol.55 (2), p.528-533
Hauptverfasser:	Rashidian, Mohammad, Wang, Lu, Edens, Jerre G., Jacobsen, Johanne T., Hossain, Intekhab, Wang, Qifan, Victora, Gabriel D., Vasdev, Neil, Ploegh, Hidde, Liang, Steven H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Avidity Biocompatibility CD11b antigen Cells, Cultured Conjugation Dimerization enzymes Fragmentation Half-Life Histocompatibility Antigens Class II - immunology Image detection Immunoglobulins In vitro methods and tests isotopic labeling Major histocompatibility complex Melanoma, Experimental - immunology Mice Molecular Imaging Nanobodies Payloads PEGylation Polyethylene glycol positron emission tomography Radioisotopes single-domain antibodies Single-Domain Antibodies - blood Single-Domain Antibodies - chemistry Single-Domain Antibodies - therapeutic use Tumors
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