Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes
The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age. Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic re...
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| Veröffentlicht in: | Journal of computer assisted tomography 2016-01, Vol.40 (1), p.53-60 |
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| creator | Cox, Simon R McKenzie, Tahlia I Aribisala, Benjamin S Royle, Natalie A MacPherson, Sarah E MacLullich, Alasdair M J Bastin, Mark E Wardlaw, Joanna M Deary, Ian J Ferguson, Karen J |
| description | The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age.
Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼ 73 years. A measure of general fluid intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery.
Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf.
Individual differences in specific frontal lobe brain volumes--variously measured--show consistent associations with cognitive ability in older age. Importantly, differences in parcellation protocol for some regions that may impact the outcome of brain-cognition analyses are discussed. |
| doi_str_mv | 10.1097/RCT.0000000000000314 |
| format | Article |
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Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼ 73 years. A measure of general fluid intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery.
Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf.
Individual differences in specific frontal lobe brain volumes--variously measured--show consistent associations with cognitive ability in older age. Importantly, differences in parcellation protocol for some regions that may impact the outcome of brain-cognition analyses are discussed.</description><identifier>ISSN: 0363-8715</identifier><identifier>ISSN: 1532-3145</identifier><identifier>EISSN: 1532-3145</identifier><identifier>DOI: 10.1097/RCT.0000000000000314</identifier><identifier>PMID: 26466114</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Aged ; Brain - pathology ; Brain Mapping - methods ; Cognition Disorders - pathology ; Frontal Lobe - pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests - statistics & numerical data ; Neuroradiology ; Organ Size ; Reproducibility of Results</subject><ispartof>Journal of computer assisted tomography, 2016-01, Vol.40 (1), p.53-60</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c329t-451cd4da76fe170fd387914c0fa6db9a402b86d6b8daf4af250e6acc958fb9da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26466114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cox, Simon R</creatorcontrib><creatorcontrib>McKenzie, Tahlia I</creatorcontrib><creatorcontrib>Aribisala, Benjamin S</creatorcontrib><creatorcontrib>Royle, Natalie A</creatorcontrib><creatorcontrib>MacPherson, Sarah E</creatorcontrib><creatorcontrib>MacLullich, Alasdair M J</creatorcontrib><creatorcontrib>Bastin, Mark E</creatorcontrib><creatorcontrib>Wardlaw, Joanna M</creatorcontrib><creatorcontrib>Deary, Ian J</creatorcontrib><creatorcontrib>Ferguson, Karen J</creatorcontrib><title>Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes</title><title>Journal of computer assisted tomography</title><addtitle>J Comput Assist Tomogr</addtitle><description>The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age.
Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼ 73 years. A measure of general fluid intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery.
Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf.
Individual differences in specific frontal lobe brain volumes--variously measured--show consistent associations with cognitive ability in older age. Importantly, differences in parcellation protocol for some regions that may impact the outcome of brain-cognition analyses are discussed.</description><subject>Aged</subject><subject>Brain - pathology</subject><subject>Brain Mapping - methods</subject><subject>Cognition Disorders - pathology</subject><subject>Frontal Lobe - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Neuroradiology</subject><subject>Organ Size</subject><subject>Reproducibility of Results</subject><issn>0363-8715</issn><issn>1532-3145</issn><issn>1532-3145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAUhS1UBFPKP0DIy25C7dixExZIdMS0SFO1anksrRs_GKMkntoZpPn39TCAgE29sa_vd47sexA6ouSEkkZ--T29OiGvF6N8B01oxcoiH6sPaEKYYEUtabWPPqZ0TwiVjPE9tF8KLgSlfILWN6Fb9XaMXmMYDJ6GGG0How8DdPiyX3ZeP1YJB4e_RvAD_gVR224L4R92XASD_9jO6s3FKT7HrLiFdbbqlxB9ylAWjQuLZzEMY7adh9amT2jXQZfs4dN-gK5nF1fT78X857fL6fm80KxsxoJXVBtuQApnqSTOsFo2lGviQJi2AU7KthZGtLUBx8GVFbECtG6q2rWNAXaAzra-y1XbW6PtMEbo1DL6HuJaBfDqbWfwC3UXHhSXtKZ1lQ0-PxnE8Hdl06h6nx4HMNiwSipTlSQb8v-oFKQWDWlIRvkW1TGkFK17eRElahOwygGr9wFn2fHr37yInhNl_wBeYqN1</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Cox, Simon R</creator><creator>McKenzie, Tahlia I</creator><creator>Aribisala, Benjamin S</creator><creator>Royle, Natalie A</creator><creator>MacPherson, Sarah E</creator><creator>MacLullich, Alasdair M J</creator><creator>Bastin, Mark E</creator><creator>Wardlaw, Joanna M</creator><creator>Deary, Ian J</creator><creator>Ferguson, Karen J</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes</title><author>Cox, Simon R ; McKenzie, Tahlia I ; Aribisala, Benjamin S ; Royle, Natalie A ; MacPherson, Sarah E ; MacLullich, Alasdair M J ; Bastin, Mark E ; Wardlaw, Joanna M ; Deary, Ian J ; Ferguson, Karen J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-451cd4da76fe170fd387914c0fa6db9a402b86d6b8daf4af250e6acc958fb9da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Brain - pathology</topic><topic>Brain Mapping - methods</topic><topic>Cognition Disorders - pathology</topic><topic>Frontal Lobe - pathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Neuroradiology</topic><topic>Organ Size</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cox, Simon R</creatorcontrib><creatorcontrib>McKenzie, Tahlia I</creatorcontrib><creatorcontrib>Aribisala, Benjamin S</creatorcontrib><creatorcontrib>Royle, Natalie A</creatorcontrib><creatorcontrib>MacPherson, Sarah E</creatorcontrib><creatorcontrib>MacLullich, Alasdair M J</creatorcontrib><creatorcontrib>Bastin, Mark E</creatorcontrib><creatorcontrib>Wardlaw, Joanna M</creatorcontrib><creatorcontrib>Deary, Ian J</creatorcontrib><creatorcontrib>Ferguson, Karen J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of computer assisted tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cox, Simon R</au><au>McKenzie, Tahlia I</au><au>Aribisala, Benjamin S</au><au>Royle, Natalie A</au><au>MacPherson, Sarah E</au><au>MacLullich, Alasdair M J</au><au>Bastin, Mark E</au><au>Wardlaw, Joanna M</au><au>Deary, Ian J</au><au>Ferguson, Karen J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes</atitle><jtitle>Journal of computer assisted tomography</jtitle><addtitle>J Comput Assist Tomogr</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>40</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0363-8715</issn><issn>1532-3145</issn><eissn>1532-3145</eissn><abstract>The aims of this study were to compare distinct brain frontal lobe parcellation methods across 90 brain magnetic resonance imaging scans and examine their associations with cognition in older age.
Three parcellation methods (Manual, FreeSurfer, and Stereology) were applied to T1-weighted magnetic resonance imaging of 90 older men, aged ∼ 73 years. A measure of general fluid intelligence (gf) associated with dorsolateral frontal regions was also derived from a contemporaneous psychological test battery.
Despite highly discordant raw volumes for the same nominal regions, Manual and FreeSurfer (but not Stereology) left dorsolateral measures were significantly correlated with gf (r > 0.22), whereas orbital and inferior lateral volumes were not, consistent with the hypothesized frontal localization of gf.
Individual differences in specific frontal lobe brain volumes--variously measured--show consistent associations with cognitive ability in older age. Importantly, differences in parcellation protocol for some regions that may impact the outcome of brain-cognition analyses are discussed.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>26466114</pmid><doi>10.1097/RCT.0000000000000314</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid Complete - AutoHoldings; MEDLINE |
| subjects | Aged Brain - pathology Brain Mapping - methods Cognition Disorders - pathology Frontal Lobe - pathology Humans Magnetic Resonance Imaging Male Neuropsychological Tests - statistics & numerical data Neuroradiology Organ Size Reproducibility of Results |
| title | Volumetric and Correlational Implications of Brain Parcellation Method Selection: A 3-Way Comparison in the Frontal Lobes |
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