High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

Recent studies found that the circulating high-mobility group box 1 (HMGB1) levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). HMGB1 could prime neutrophils by increasing ANCA antigens translocation for ANCA-mediated respiratory burst...

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Veröffentlicht in:	Arthritis research & therapy 2016-01, Vol.18 (2), p.2-2, Article 2
Hauptverfasser:	Ma, Yun-Hua, Ma, Tian-Tian, Wang, Chen, Wang, Huan, Chang, Dong-Yuan, Chen, Min, Zhao, Ming-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - metabolism Antibodies, Antineutrophil Cytoplasmic - pharmacology Arthritis Biological markers Care and treatment Crohn's disease Dose-Response Relationship, Drug Drug Synergism Extracellular Traps - drug effects Extracellular Traps - metabolism HMGB1 Protein - pharmacology Humans Influence Neutrophils Neutrophils - drug effects Neutrophils - metabolism
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