Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis
Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone...
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| Veröffentlicht in: | Arthritis research & therapy 2015-12, Vol.17 (379), p.377-377, Article 377 |
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| creator | Nigil Haroon, Nisha Szabo, Eva Raboud, Janet M Mcdonald-Blumer, Heather Fung, Lydia Josse, Robert G Inman, Robert D Cheung, Angela M |
| description | Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microarchitecture and strength.
Patients with AS (n = 53) and non-AS subjects (n = 85) were recruited for the study. All subjects underwent clinical evaluation, DXA and high-resolution peripheral quantitative CT scans (HRpQCT).
The AS patients were aged 44 ± 12 (mean ± standard deviation) years and had a median disease duration of 17 (interquartile range: 7-27) years. They were found to have lower cortical, trabecular and total vBMD at the distal radius and tibia than non-AS subjects on multivariable regression analysis. Cortical parameters such as cortical thickness and porosity, and bone strength parameters such bone stiffness and stress as estimated by finite element analysis (FEA) in AS patients were significantly worse than that of-non-AS subjects. Among patients with AS, male sex, mSASSS greater than zero and HLA-B27 negative status were associated with worse bone microarchitecture.
Patients with AS have worse bone mineral density, microarchitecture and strength when compared to non-AS subjects. More research is needed to understand the mechanisms underlying bone pathology in AS and to assess the effect of treatments such as TNF inhibitors on bone quality and fracture risk. |
| doi_str_mv | 10.1186/s13075-015-0873-1 |
| format | Article |
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Patients with AS (n = 53) and non-AS subjects (n = 85) were recruited for the study. All subjects underwent clinical evaluation, DXA and high-resolution peripheral quantitative CT scans (HRpQCT).
The AS patients were aged 44 ± 12 (mean ± standard deviation) years and had a median disease duration of 17 (interquartile range: 7-27) years. They were found to have lower cortical, trabecular and total vBMD at the distal radius and tibia than non-AS subjects on multivariable regression analysis. Cortical parameters such as cortical thickness and porosity, and bone strength parameters such bone stiffness and stress as estimated by finite element analysis (FEA) in AS patients were significantly worse than that of-non-AS subjects. Among patients with AS, male sex, mSASSS greater than zero and HLA-B27 negative status were associated with worse bone microarchitecture.
Patients with AS have worse bone mineral density, microarchitecture and strength when compared to non-AS subjects. More research is needed to understand the mechanisms underlying bone pathology in AS and to assess the effect of treatments such as TNF inhibitors on bone quality and fracture risk.</description><identifier>ISSN: 1478-6362</identifier><identifier>ISSN: 1478-6354</identifier><identifier>EISSN: 1478-6362</identifier><identifier>DOI: 10.1186/s13075-015-0873-1</identifier><identifier>PMID: 26704700</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Absorptiometry, Photon ; Adult ; Analysis ; Ankylosing spondylitis ; Arthritis ; Bone and Bones - diagnostic imaging ; Bone Density - physiology ; Bones ; Complications and side effects ; Cross-Sectional Studies ; CT imaging ; Density ; Female ; Finite Element Analysis ; Humans ; Male ; Middle Aged ; Observational studies ; Osteoporosis ; Risk factors ; Spondylitis, Ankylosing - diagnostic imaging ; Tomography, X-Ray Computed - methods</subject><ispartof>Arthritis research & therapy, 2015-12, Vol.17 (379), p.377-377, Article 377</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Nigil Haroon et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-d38e6fc88a20013b2666242478fea1b9a508b1a6bfa17ff77ef93fbbbba154493</citedby><cites>FETCH-LOGICAL-c494t-d38e6fc88a20013b2666242478fea1b9a508b1a6bfa17ff77ef93fbbbba154493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718021/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718021/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26704700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nigil Haroon, Nisha</creatorcontrib><creatorcontrib>Szabo, Eva</creatorcontrib><creatorcontrib>Raboud, Janet M</creatorcontrib><creatorcontrib>Mcdonald-Blumer, Heather</creatorcontrib><creatorcontrib>Fung, Lydia</creatorcontrib><creatorcontrib>Josse, Robert G</creatorcontrib><creatorcontrib>Inman, Robert D</creatorcontrib><creatorcontrib>Cheung, Angela M</creatorcontrib><title>Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis</title><title>Arthritis research & therapy</title><addtitle>Arthritis Res Ther</addtitle><description>Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microarchitecture and strength.
Patients with AS (n = 53) and non-AS subjects (n = 85) were recruited for the study. All subjects underwent clinical evaluation, DXA and high-resolution peripheral quantitative CT scans (HRpQCT).
The AS patients were aged 44 ± 12 (mean ± standard deviation) years and had a median disease duration of 17 (interquartile range: 7-27) years. They were found to have lower cortical, trabecular and total vBMD at the distal radius and tibia than non-AS subjects on multivariable regression analysis. Cortical parameters such as cortical thickness and porosity, and bone strength parameters such bone stiffness and stress as estimated by finite element analysis (FEA) in AS patients were significantly worse than that of-non-AS subjects. Among patients with AS, male sex, mSASSS greater than zero and HLA-B27 negative status were associated with worse bone microarchitecture.
Patients with AS have worse bone mineral density, microarchitecture and strength when compared to non-AS subjects. More research is needed to understand the mechanisms underlying bone pathology in AS and to assess the effect of treatments such as TNF inhibitors on bone quality and fracture risk.</description><subject>Absorptiometry, Photon</subject><subject>Adult</subject><subject>Analysis</subject><subject>Ankylosing spondylitis</subject><subject>Arthritis</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone Density - physiology</subject><subject>Bones</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>CT imaging</subject><subject>Density</subject><subject>Female</subject><subject>Finite Element Analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational studies</subject><subject>Osteoporosis</subject><subject>Risk factors</subject><subject>Spondylitis, Ankylosing - diagnostic imaging</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1478-6362</issn><issn>1478-6354</issn><issn>1478-6362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUstu1TAUjBCIlsIHsEGW2LAgxc7DTlggXVW8pEpsYG05yXHiktip7RSFX-YnOLm3rW4RiSJH4zlz5tiTJC8ZPWes4u8Cy6koU8rwq0SeskfJKStElfKcZ4-P_k-SZyFcUZpldVY8TU4yLmghKD1N_uzGCF5F42wgTpPGWSCTsYiNpAMbTFzf3qGtd8q3g4nQxsUDUbYjIXqwfRyIsWRGHbAxkF8GAWV_rqMLxvYkzM5262iiCe-JIqgTQhpQBdtinxCXbiXLnjqYfkg9BDcu2y6ZwZt52Nu5XpSNJmKTGyCtm-YFrZvf0JHoJtd7NQ_r3pM2Fj0SGGFCOwipcQ0mPE-eaDUGeHG7niU_Pn38fvElvfz2-evF7jJti7qIaZdXwHVbVSqjlOVNxjnPigzPUoNiTa1KWjVM8UYrJrQWAnSd6wYfxcqiqPOz5MNBd16aCboWPaB9OXszKb9Kp4x8uGPNIHt3IwvBKpoxFHhzK-Dd9QIhysmEFsZRWXBLkEyUWVmVjFZIff0P9cotHgfeWIIJXhXsiNWrEaSx2mHfdhOVu6JkvBRlTpF1_h8Wvh3g3WMEtEH8QQE7FOwv1IO-n5FRuSVUHhIqMaFyS6jcZnt1fDj3FXeRzP8CYdjqBg</recordid><startdate>20151224</startdate><enddate>20151224</enddate><creator>Nigil Haroon, Nisha</creator><creator>Szabo, Eva</creator><creator>Raboud, Janet M</creator><creator>Mcdonald-Blumer, Heather</creator><creator>Fung, Lydia</creator><creator>Josse, Robert G</creator><creator>Inman, Robert D</creator><creator>Cheung, Angela M</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151224</creationdate><title>Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis</title><author>Nigil Haroon, Nisha ; Szabo, Eva ; Raboud, Janet M ; Mcdonald-Blumer, Heather ; Fung, Lydia ; Josse, Robert G ; Inman, Robert D ; Cheung, Angela M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-d38e6fc88a20013b2666242478fea1b9a508b1a6bfa17ff77ef93fbbbba154493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Absorptiometry, Photon</topic><topic>Adult</topic><topic>Analysis</topic><topic>Ankylosing spondylitis</topic><topic>Arthritis</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone Density - physiology</topic><topic>Bones</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>CT imaging</topic><topic>Density</topic><topic>Female</topic><topic>Finite Element Analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational studies</topic><topic>Osteoporosis</topic><topic>Risk factors</topic><topic>Spondylitis, Ankylosing - diagnostic imaging</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nigil Haroon, Nisha</creatorcontrib><creatorcontrib>Szabo, Eva</creatorcontrib><creatorcontrib>Raboud, Janet M</creatorcontrib><creatorcontrib>Mcdonald-Blumer, Heather</creatorcontrib><creatorcontrib>Fung, Lydia</creatorcontrib><creatorcontrib>Josse, Robert G</creatorcontrib><creatorcontrib>Inman, Robert D</creatorcontrib><creatorcontrib>Cheung, Angela M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis research & therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nigil Haroon, Nisha</au><au>Szabo, Eva</au><au>Raboud, Janet M</au><au>Mcdonald-Blumer, Heather</au><au>Fung, Lydia</au><au>Josse, Robert G</au><au>Inman, Robert D</au><au>Cheung, Angela M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis</atitle><jtitle>Arthritis research & therapy</jtitle><addtitle>Arthritis Res Ther</addtitle><date>2015-12-24</date><risdate>2015</risdate><volume>17</volume><issue>379</issue><spage>377</spage><epage>377</epage><pages>377-377</pages><artnum>377</artnum><issn>1478-6362</issn><issn>1478-6354</issn><eissn>1478-6362</eissn><abstract>Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microarchitecture and strength.
Patients with AS (n = 53) and non-AS subjects (n = 85) were recruited for the study. All subjects underwent clinical evaluation, DXA and high-resolution peripheral quantitative CT scans (HRpQCT).
The AS patients were aged 44 ± 12 (mean ± standard deviation) years and had a median disease duration of 17 (interquartile range: 7-27) years. They were found to have lower cortical, trabecular and total vBMD at the distal radius and tibia than non-AS subjects on multivariable regression analysis. Cortical parameters such as cortical thickness and porosity, and bone strength parameters such bone stiffness and stress as estimated by finite element analysis (FEA) in AS patients were significantly worse than that of-non-AS subjects. Among patients with AS, male sex, mSASSS greater than zero and HLA-B27 negative status were associated with worse bone microarchitecture.
Patients with AS have worse bone mineral density, microarchitecture and strength when compared to non-AS subjects. More research is needed to understand the mechanisms underlying bone pathology in AS and to assess the effect of treatments such as TNF inhibitors on bone quality and fracture risk.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26704700</pmid><doi>10.1186/s13075-015-0873-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Adult Analysis Ankylosing spondylitis Arthritis Bone and Bones - diagnostic imaging Bone Density - physiology Bones Complications and side effects Cross-Sectional Studies CT imaging Density Female Finite Element Analysis Humans Male Middle Aged Observational studies Osteoporosis Risk factors Spondylitis, Ankylosing - diagnostic imaging Tomography, X-Ray Computed - methods |
| title | Alterations of bone mineral density, bone microarchitecture and strength in patients with ankylosing spondylitis: a cross-sectional study using high-resolution peripheral quantitative computerized tomography and finite element analysis |
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