Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein

It has previously been suggested that reactive oxygen species (ROS) are involved in the pathogenesis of chronic inflammatory diseases, which entails the initial activation of pro-inflammatory cytokines to facilitate leukocyte transmigration. The present study investigated whether intracellular super...

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Veröffentlicht in:	International journal of molecular medicine 2016-02, Vol.37 (2), p.387-397
Hauptverfasser:	PARK, SIN-HYE, SHIN, MIN JAE, KIM, DAE WON, PARK, JINSEU, CHOI, SOO YOUNG, KANG, YOUNG-HEE
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Atherosclerosis Atherosclerosis - genetics Atherosclerosis - pathology Cell adhesion & migration Cyclic AMP Response Element-Binding Protein Cytokines Development and progression E coli Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Genetic aspects Human Umbilical Vein Endothelial Cells Humans Hypoxia Inflammation Inflammation - genetics Inflammation - pathology Kinases Monocytes - metabolism Monocytes - pathology NF-kappa B - biosynthesis nuclear factor-κB occludin-1 Oxidation-Reduction - drug effects Oxidative stress Peptides Physiological aspects Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Protein Transport - drug effects Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Rodents superoxide anion Superoxide dismutase Superoxide Dismutase - biosynthesis Superoxide Dismutase - genetics Superoxide Dismutase-1 Tat-superoxide dismutase Transcriptional Activation Transduction, Genetic Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-TNF vascular cell adhesion molecule-1 Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular endothelial growth factor
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