Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

Heritable mutations in the BAP1 tumor suppressor gene predispose individuals to mesothelioma and other cancers. However, a large-scale assessment of germline BAP1 mutation incidence and associated clinical features in mesothelioma patients with a family history of cancer has not been reported. There...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-01, Vol.76 (2), p.206-215
Hauptverfasser:	Ohar, Jill A, Cheung, Mitchell, Talarchek, Jacqueline, Howard, Suzanne E, Howard, Timothy D, Hesdorffer, Mary, Peng, Hongzhuang, Rauscher, Frank J, Testa, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Asbestos - adverse effects Cohort Studies Female Genetic Predisposition to Disease Germ-Line Mutation HEK293 Cells Humans Lung Neoplasms - etiology Lung Neoplasms - genetics Male Mesothelioma - etiology Mesothelioma - genetics Mesothelioma, Malignant Middle Aged Mutation, Missense Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism
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