BLOCKADE OF ENDOTHELIAL GROWTH FACTOR, ANGIOPOIETIN-2, REDUCES INDICES OF ARDS AND MORTALITY IN MICE RESULTING FROM THE DUAL-INSULTS OF HEMORRHAGIC SHOCK AND SEPSIS

ABSTRACTWe have demonstrated hemorrhagic shock “priming” for the development of indirect acute respiratory distress syndrome (iARDS) in mice following subsequent septic challenge, and show pathology characteristic of patients with iARDS, including increased lung microvascular permeability and arteri...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2016-02, Vol.45 (2), p.157-165
Hauptverfasser:	Lomas-Neira, Joanne L, Heffernan, Daithi S, Ayala, Alfred, Monaghan, Sean F
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-2 - blood Animals Endothelial Growth Factors - blood Inflammation - blood Inflammation - metabolism Male Mice Mice, Inbred C57BL Sepsis - blood Sepsis - metabolism Sepsis - mortality Shock, Hemorrhagic - blood Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - mortality
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