NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

Stem cell markers, including NANOG, have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. Here, we show that NANOG is induced by Toll-like receptor 4 (TLR4) signaling via phosphorylation of E2F1 and that downregulation of...

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Veröffentlicht in:	Cell metabolism 2016-01, Vol.23 (1), p.206-219
Hauptverfasser:	Chen, Chia-Lin, Uthaya Kumar, Dinesh Babu, Punj, Vasu, Xu, Jun, Sher, Linda, Tahara, Stanley M., Hess, Sonja, Machida, Keigo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - metabolism Carcinogenesis - pathology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Self Renewal Drug Resistance, Neoplasm E2F1 Transcription Factor - metabolism fatty acid Fatty Acids Gene Expression Regulation, Neoplastic HCC HEK293 Cells Homeodomain Proteins - physiology Humans Lipid Metabolism liver Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology metabolic reprogramming Mitochondria, Liver - metabolism NANOG Nanog Homeobox Protein Neoplastic Stem Cells - metabolism Oxidation-Reduction Oxidative Phosphorylation Oxidative Stress OXPHOS Phosphorylation Protein Processing, Post-Translational Reactive Oxygen Species - metabolism self-renewal Transcriptional Activation tumor-initiating stem-like cells (TICs)
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