Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β‐catenin and nuclear factor‐κB pathways

Retinoid X receptor α (RXRα) plays important roles in the malignancy of several cancers such as human prostate tumor, breast cancer, and thyroid tumor. However, its exact functions and molecular mechanisms in cholangiocarcinoma (CCA), a chemoresistant carcinoma with poor prognosis, remain unclear. I...

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Veröffentlicht in:	Cancer science 2015-11, Vol.106 (11), p.1515-1523
Hauptverfasser:	Huang, Gui‐Li, Zhang, Wei, Ren, Hong‐Yue, Shen, Xue‐Ying, Chen, Qing‐Xi, Shen, Dong‐Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over beta Catenin - metabolism Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Blotting, Western Breast cancer Cancer therapies Catenin Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - physiology Cell Survival - physiology Cholangiocarcinoma Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Cyclin D1 Cyclin E Cyclin-dependent kinase inhibitor p21 Deoxyribonucleic acid DNA Female Flow Cytometry Fluorescent Antibody Technique Gene expression Humans Immunoglobulins Immunohistochemistry Male Malignancy Medical prognosis Middle Aged Mitosis Molecular modelling NF-kappa B - metabolism NF‐κB Original Proliferating cell nuclear antigen proliferation Prostate cancer Proteins Real-Time Polymerase Chain Reaction Retinoid X Receptor alpha - metabolism retinoid X receptor α Signal transduction Signal Transduction - physiology Studies Thyroid cancer Thyroid gland Transcription factors Transfection Wnt protein Wnt Proteins - metabolism β‐catenin
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