Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration

The low-density lipoprotein receptor-related protein receptors 1 and 2 (LRP1 and LRP2) are emerging as important cell signaling mediators in modulating neuronal growth and repair. We examined whether LRP1 and LRP2 are able to mediate a specific aspect of neuronal growth: axon guidance. We sought to...

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Veröffentlicht in:	The Journal of biological chemistry 2016-01, Vol.291 (3), p.1092-1102
Hauptverfasser:	Landowski, Lila M., Pavez, Macarena, Brown, Lachlan S., Gasperini, Robert, Taylor, Bruce V., West, Adrian K., Foa, Lisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals axon Axons - drug effects Axons - physiology Calcium Signaling - drug effects cell signaling Cells, Cultured Chemotaxis - drug effects Epidermis - drug effects Epidermis - innervation Ganglia, Spinal - cytology Ganglia, Spinal - drug effects Ganglia, Spinal - physiology growth cone Growth Cones - drug effects Growth Cones - metabolism Ligands Low Density Lipoprotein Receptor-Related Protein-1 - agonists Low Density Lipoprotein Receptor-Related Protein-1 - antagonists & inhibitors Low Density Lipoprotein Receptor-Related Protein-1 - genetics Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Low Density Lipoprotein Receptor-Related Protein-2 - agonists Low Density Lipoprotein Receptor-Related Protein-2 - antagonists & inhibitors Low Density Lipoprotein Receptor-Related Protein-2 - genetics Low Density Lipoprotein Receptor-Related Protein-2 - metabolism LRP1 LRP2 Male metallothionein Metallothionein - pharmacology Metallothionein - therapeutic use Nerve Regeneration - drug effects Nerve Tissue Proteins - agonists Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism neurite outgrowth Neurobiology Neurogenesis - drug effects Peripheral Nerves - cytology Peripheral Nerves - drug effects Peripheral Nerves - physiology Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - physiopathology Rabbits Rats, Sprague-Dawley regeneration RNA Interference
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