Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2

CARMILs regulate capping protein (CP), a critical determinant of actin assembly and actin-based cell motility. Vertebrates have three conserved CARMIL genes with distinct functions. In migrating cells, CARMIL2 is important for cell polarity, lamellipodial assembly, ruffling, and macropinocytosis. In...

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Veröffentlicht in:	The Journal of biological chemistry 2016-01, Vol.291 (3), p.1076-1091
Hauptverfasser:	Lanier, M. Hunter, McConnell, Patrick, Cooper, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence capping protein Cell Biology Cell Line Cell Membrane - metabolism cell migration Cell Movement cell polarity Conserved Sequence Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Databases, Protein Humans Hydrophobic and Hydrophilic Interactions Intermediate Filaments - metabolism invadopodia lamellipodia lipid binding Liposomes Luminescent Proteins - genetics Luminescent Proteins - metabolism Microfilament Proteins - antagonists & inhibitors Microfilament Proteins - chemistry Microfilament Proteins - genetics Microfilament Proteins - metabolism Mutation Peptide Fragments - antagonists & inhibitors Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism plasma membrane Podosomes - metabolism Protein Interaction Domains and Motifs Protein Isoforms - antagonists & inhibitors Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Transport Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RLTPR RNA Interference vimentin Vimentin - metabolism
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