Role of microRNA-7 in digestive system malignancy
There are several malignancies of the digestive system（including gastric, pancreatic and colorectal cancers, andhepatocellular carcinoma）, which are the most commontypes of cancer and a major cause of death worldwide.MicroRNA （miR）-7 is abundant in the pancreas, playingan important role in pancreati...
Gespeichert in:
| Veröffentlicht in: | World journal of gastrointestinal oncology 2016-01, Vol.8 (1), p.121-127 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127 |
|---|---|
| container_issue | 1 |
| container_start_page | 121 |
| container_title | World journal of gastrointestinal oncology |
| container_volume | 8 |
| creator | Chen, Wan-Qun Hu, Ling Chen, Geng-Xin Deng, Hai-Xia |
| description | There are several malignancies of the digestive system（including gastric, pancreatic and colorectal cancers, andhepatocellular carcinoma）, which are the most commontypes of cancer and a major cause of death worldwide.MicroRNA （miR）-7 is abundant in the pancreas, playingan important role in pancreatic development andendocrine function. Expression of miR-7 is downregulatedin digestive system malignancies compared with normaltissue. Although there are contrasting results for miR-7expression, almost all research reveals that miR-7 is atumor suppressor, by targeting various genes in specificpathways. Moreover, miR-7 can target different genessimultaneously in different malignancies of the digestivesystem. By acting on many cytokines, miR-7 is alsoinvolved in many gastrointestinal inflammatory diseasesas a significant carcinogenic factor. Consequently, miR-7might be a biomarker or therapeutic target gene indigestive system malignancies. |
| doi_str_mv | 10.4251/wjgo.v8.i1.121 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4714141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>667942205</cqvip_id><sourcerecordid>26798443</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-ad1b4c8400cb9b7f5c9fd4161d85772d19a1ada7cfbcd1f00af84495693199663</originalsourceid><addsrcrecordid>eNpVUE1rwzAMNWNjLV2vO46wezIrceL4MihlX1A2KNvZOP5IXfLRxVlK__1c2pVOOkig956kh9At4IjEKTxs12UbDXlkIYIYLtAYGMnDNMbk8qwfoalza-yDEIoBX6NRnFGWE5KMESzbSgetCWoru3b5PgtpYJtA2VK73g46cDvX6zqoRWXLRjRyd4OujKicnh7rBH09P33OX8PFx8vbfLYIJQHah0JBQWROMJYFK6hJJTOKQAYqTymNFTABQgkqTSEVGIyF8RexNGMJMJZlyQQ9HnQ3P0WtldRN34mKbzpbi27HW2H5_0ljV7xsB04oEJ9eIDoI-Mec67Q5cQHzvX987x8fcm6Be_884e584wn-55YH3B8VV21TftumPGEyjyFxjNPkF_DyeMY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Role of microRNA-7 in digestive system malignancy</title><source>Baishideng "World Journal of" online journals</source><source>NCBI_PubMed Central（免费）</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Chen, Wan-Qun ; Hu, Ling ; Chen, Geng-Xin ; Deng, Hai-Xia</creator><creatorcontrib>Chen, Wan-Qun ; Hu, Ling ; Chen, Geng-Xin ; Deng, Hai-Xia</creatorcontrib><description>There are several malignancies of the digestive system（including gastric, pancreatic and colorectal cancers, andhepatocellular carcinoma）, which are the most commontypes of cancer and a major cause of death worldwide.MicroRNA （miR）-7 is abundant in the pancreas, playingan important role in pancreatic development andendocrine function. Expression of miR-7 is downregulatedin digestive system malignancies compared with normaltissue. Although there are contrasting results for miR-7expression, almost all research reveals that miR-7 is atumor suppressor, by targeting various genes in specificpathways. Moreover, miR-7 can target different genessimultaneously in different malignancies of the digestivesystem. By acting on many cytokines, miR-7 is alsoinvolved in many gastrointestinal inflammatory diseasesas a significant carcinogenic factor. Consequently, miR-7might be a biomarker or therapeutic target gene indigestive system malignancies.</description><identifier>ISSN: 1948-5204</identifier><identifier>EISSN: 1948-5204</identifier><identifier>DOI: 10.4251/wjgo.v8.i1.121</identifier><identifier>PMID: 26798443</identifier><language>eng</language><publisher>China: Baishideng Publishing Group Inc</publisher><subject>biomarker ; Digestive ; gene ; Inflammation ; malignancy;Tumor ; MicroRNA-7 ; Minireviews ; system ; Target</subject><ispartof>World journal of gastrointestinal oncology, 2016-01, Vol.8 (1), p.121-127</ispartof><rights>The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-ad1b4c8400cb9b7f5c9fd4161d85772d19a1ada7cfbcd1f00af84495693199663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71425X/71425X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714141/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714141/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26798443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wan-Qun</creatorcontrib><creatorcontrib>Hu, Ling</creatorcontrib><creatorcontrib>Chen, Geng-Xin</creatorcontrib><creatorcontrib>Deng, Hai-Xia</creatorcontrib><title>Role of microRNA-7 in digestive system malignancy</title><title>World journal of gastrointestinal oncology</title><addtitle>World Journal of Gastrointestinal Oncology</addtitle><description>There are several malignancies of the digestive system（including gastric, pancreatic and colorectal cancers, andhepatocellular carcinoma）, which are the most commontypes of cancer and a major cause of death worldwide.MicroRNA （miR）-7 is abundant in the pancreas, playingan important role in pancreatic development andendocrine function. Expression of miR-7 is downregulatedin digestive system malignancies compared with normaltissue. Although there are contrasting results for miR-7expression, almost all research reveals that miR-7 is atumor suppressor, by targeting various genes in specificpathways. Moreover, miR-7 can target different genessimultaneously in different malignancies of the digestivesystem. By acting on many cytokines, miR-7 is alsoinvolved in many gastrointestinal inflammatory diseasesas a significant carcinogenic factor. Consequently, miR-7might be a biomarker or therapeutic target gene indigestive system malignancies.</description><subject>biomarker</subject><subject>Digestive</subject><subject>gene</subject><subject>Inflammation</subject><subject>malignancy;Tumor</subject><subject>MicroRNA-7</subject><subject>Minireviews</subject><subject>system</subject><subject>Target</subject><issn>1948-5204</issn><issn>1948-5204</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVUE1rwzAMNWNjLV2vO46wezIrceL4MihlX1A2KNvZOP5IXfLRxVlK__1c2pVOOkig956kh9At4IjEKTxs12UbDXlkIYIYLtAYGMnDNMbk8qwfoalza-yDEIoBX6NRnFGWE5KMESzbSgetCWoru3b5PgtpYJtA2VK73g46cDvX6zqoRWXLRjRyd4OujKicnh7rBH09P33OX8PFx8vbfLYIJQHah0JBQWROMJYFK6hJJTOKQAYqTymNFTABQgkqTSEVGIyF8RexNGMJMJZlyQQ9HnQ3P0WtldRN34mKbzpbi27HW2H5_0ljV7xsB04oEJ9eIDoI-Mec67Q5cQHzvX987x8fcm6Be_884e584wn-55YH3B8VV21TftumPGEyjyFxjNPkF_DyeMY</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>Chen, Wan-Qun</creator><creator>Hu, Ling</creator><creator>Chen, Geng-Xin</creator><creator>Deng, Hai-Xia</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160115</creationdate><title>Role of microRNA-7 in digestive system malignancy</title><author>Chen, Wan-Qun ; Hu, Ling ; Chen, Geng-Xin ; Deng, Hai-Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ad1b4c8400cb9b7f5c9fd4161d85772d19a1ada7cfbcd1f00af84495693199663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>biomarker</topic><topic>Digestive</topic><topic>gene</topic><topic>Inflammation</topic><topic>malignancy;Tumor</topic><topic>MicroRNA-7</topic><topic>Minireviews</topic><topic>system</topic><topic>Target</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wan-Qun</creatorcontrib><creatorcontrib>Hu, Ling</creatorcontrib><creatorcontrib>Chen, Geng-Xin</creatorcontrib><creatorcontrib>Deng, Hai-Xia</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastrointestinal oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wan-Qun</au><au>Hu, Ling</au><au>Chen, Geng-Xin</au><au>Deng, Hai-Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of microRNA-7 in digestive system malignancy</atitle><jtitle>World journal of gastrointestinal oncology</jtitle><addtitle>World Journal of Gastrointestinal Oncology</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>8</volume><issue>1</issue><spage>121</spage><epage>127</epage><pages>121-127</pages><issn>1948-5204</issn><eissn>1948-5204</eissn><abstract>There are several malignancies of the digestive system（including gastric, pancreatic and colorectal cancers, andhepatocellular carcinoma）, which are the most commontypes of cancer and a major cause of death worldwide.MicroRNA （miR）-7 is abundant in the pancreas, playingan important role in pancreatic development andendocrine function. Expression of miR-7 is downregulatedin digestive system malignancies compared with normaltissue. Although there are contrasting results for miR-7expression, almost all research reveals that miR-7 is atumor suppressor, by targeting various genes in specificpathways. Moreover, miR-7 can target different genessimultaneously in different malignancies of the digestivesystem. By acting on many cytokines, miR-7 is alsoinvolved in many gastrointestinal inflammatory diseasesas a significant carcinogenic factor. Consequently, miR-7might be a biomarker or therapeutic target gene indigestive system malignancies.</abstract><cop>China</cop><pub>Baishideng Publishing Group Inc</pub><pmid>26798443</pmid><doi>10.4251/wjgo.v8.i1.121</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1948-5204 |
| ispartof | World journal of gastrointestinal oncology, 2016-01, Vol.8 (1), p.121-127 |
| issn | 1948-5204 1948-5204 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4714141 |
| source | Baishideng "World Journal of" online journals; NCBI_PubMed Central（免费）; Free E-Journal (出版社公開部分のみ） |
| subjects | biomarker Digestive gene Inflammation malignancy Tumor MicroRNA-7 Minireviews system Target |
| title | Role of microRNA-7 in digestive system malignancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T13%3A49%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20microRNA-7%20in%20digestive%20system%20malignancy&rft.jtitle=World%20journal%20of%20gastrointestinal%20oncology&rft.au=Chen,%20Wan-Qun&rft.date=2016-01-15&rft.volume=8&rft.issue=1&rft.spage=121&rft.epage=127&rft.pages=121-127&rft.issn=1948-5204&rft.eissn=1948-5204&rft_id=info:doi/10.4251/wjgo.v8.i1.121&rft_dat=%3Cpubmed_cross%3E26798443%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/26798443&rft_cqvip_id=667942205&rfr_iscdi=true |