Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes

Determining the relationships between the structures of substrates and inhibitors and their interactions with drug-metabolizing enzymes is of prime importance in predicting the toxic potential of new and legacy xenobiotics. Traditionally, quantitative structure activity relationship (QSAR) studies a...

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Veröffentlicht in:	Environmental science and pollution research international 2016-02, Vol.23 (3), p.2119-2127
Hauptverfasser:	Ekuase, E. J, van ‘t Erve, T. J, Rahaman, A, Robertson, L. W, Duffel, M. W, Luthe, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioaccumulation Chemical properties Earth and Environmental Science Ecotoxicology Effects Environment Environmental Chemistry Environmental Health Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme kinetics Enzymes Fluorine Human exposure Humans Hydroxylation in vitro studies Investigations Metabolism Metabolites PCB PCBs: Exposures physicochemical properties Pollutants Pollution studies Polychlorinated biphenyls Polychlorinated Biphenyls - chemistry Polychlorinated Biphenyls - metabolism prediction Quantitative Structure-Activity Relationship quantitative structure-activity relationships Remediation and Regulation with special reference to PCBs in Schools Substrates Sulfotransferases - chemistry Sulfotransferases - metabolism Toxicity Toxicology Waste Water Technology Water Management Water Pollution Control Xenobiotics
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