Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension
Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-02, Vol.67 (2), p.469-474 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 474 |
|---|---|
| container_issue | 2 |
| container_start_page | 469 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 67 |
| creator | Durgan, David J Ganesh, Bhanu P Cope, Julia L Ajami, Nadim J Phillips, Sharon C Petrosino, Joseph F Hollister, Emily B Bryan, Jr, Robert M |
| description | Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.115.06672 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4713369</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760875518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c549t-e0a0eaa51b262a3abe90e3f49b7759c1938862adbdf48266cbd1942862f892903</originalsourceid><addsrcrecordid>eNpdUctO3DAUtVBRmdL-QuXuugn4xq94U2mEpswgYCoeEqwsJ7kpRpk4xAkSf49bHgJWVzr3nHMfh5AfwPYAFOwvr_8szi4Wp-er9el8OU-g3GNK6XyLzEDmIhNS8U9kxsCIzABc7ZAvMd4yBkII_Zns5EoDaG5m5OgstEhDQ8cbpIfTSE98NYTShw1S39F1GcdhqkZ_j_S8RezpvO_QZauuniqs6fKhx2HELvrQfSXbjWsjfnuuu-Ty9-LiYJkdrw9XB_PjrJLCjBkyx9A5CWWucsddiYYhb4QptZamAsOLIjXqsm5EkStVlXU6I09YU5jcML5Lfj359lO5wbrCbhxca_vBb9zwYIPz9n2n8zf2b7i3QgPnyiSDn88GQ7ibMI5242OFbes6DFO0oBUrtJRQJKp5oqanxDhg8zoGmP2Xhf2QRQKl_Z9F0n5_u-er8uX5_BEaOohP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1760875518</pqid></control><display><type>article</type><title>Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Durgan, David J ; Ganesh, Bhanu P ; Cope, Julia L ; Ajami, Nadim J ; Phillips, Sharon C ; Petrosino, Joseph F ; Hollister, Emily B ; Bryan, Jr, Robert M</creator><creatorcontrib>Durgan, David J ; Ganesh, Bhanu P ; Cope, Julia L ; Ajami, Nadim J ; Phillips, Sharon C ; Petrosino, Joseph F ; Hollister, Emily B ; Bryan, Jr, Robert M</creatorcontrib><description>Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P<0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate (P<0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P<0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.115.06672</identifier><identifier>PMID: 26711739</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Blood Pressure - physiology ; Disease Models, Animal ; Dysbiosis - complications ; Dysbiosis - microbiology ; Gastrointestinal Microbiome - physiology ; Hypertension - etiology ; Hypertension - physiopathology ; Male ; Polysomnography ; Rats ; Rats, Long-Evans ; Sleep - physiology ; Sleep Apnea Syndromes - complications ; Sleep Apnea Syndromes - microbiology ; Sleep Apnea Syndromes - physiopathology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2016-02, Vol.67 (2), p.469-474</ispartof><rights>2015 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-e0a0eaa51b262a3abe90e3f49b7759c1938862adbdf48266cbd1942862f892903</citedby><cites>FETCH-LOGICAL-c549t-e0a0eaa51b262a3abe90e3f49b7759c1938862adbdf48266cbd1942862f892903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26711739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durgan, David J</creatorcontrib><creatorcontrib>Ganesh, Bhanu P</creatorcontrib><creatorcontrib>Cope, Julia L</creatorcontrib><creatorcontrib>Ajami, Nadim J</creatorcontrib><creatorcontrib>Phillips, Sharon C</creatorcontrib><creatorcontrib>Petrosino, Joseph F</creatorcontrib><creatorcontrib>Hollister, Emily B</creatorcontrib><creatorcontrib>Bryan, Jr, Robert M</creatorcontrib><title>Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P<0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate (P<0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P<0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.</description><subject>Animals</subject><subject>Blood Pressure - physiology</subject><subject>Disease Models, Animal</subject><subject>Dysbiosis - complications</subject><subject>Dysbiosis - microbiology</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Polysomnography</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Sleep - physiology</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Apnea Syndromes - microbiology</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctO3DAUtVBRmdL-QuXuugn4xq94U2mEpswgYCoeEqwsJ7kpRpk4xAkSf49bHgJWVzr3nHMfh5AfwPYAFOwvr_8szi4Wp-er9el8OU-g3GNK6XyLzEDmIhNS8U9kxsCIzABc7ZAvMd4yBkII_Zns5EoDaG5m5OgstEhDQ8cbpIfTSE98NYTShw1S39F1GcdhqkZ_j_S8RezpvO_QZauuniqs6fKhx2HELvrQfSXbjWsjfnuuu-Ty9-LiYJkdrw9XB_PjrJLCjBkyx9A5CWWucsddiYYhb4QptZamAsOLIjXqsm5EkStVlXU6I09YU5jcML5Lfj359lO5wbrCbhxca_vBb9zwYIPz9n2n8zf2b7i3QgPnyiSDn88GQ7ibMI5242OFbes6DFO0oBUrtJRQJKp5oqanxDhg8zoGmP2Xhf2QRQKl_Z9F0n5_u-er8uX5_BEaOohP</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Durgan, David J</creator><creator>Ganesh, Bhanu P</creator><creator>Cope, Julia L</creator><creator>Ajami, Nadim J</creator><creator>Phillips, Sharon C</creator><creator>Petrosino, Joseph F</creator><creator>Hollister, Emily B</creator><creator>Bryan, Jr, Robert M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension</title><author>Durgan, David J ; Ganesh, Bhanu P ; Cope, Julia L ; Ajami, Nadim J ; Phillips, Sharon C ; Petrosino, Joseph F ; Hollister, Emily B ; Bryan, Jr, Robert M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-e0a0eaa51b262a3abe90e3f49b7759c1938862adbdf48266cbd1942862f892903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Blood Pressure - physiology</topic><topic>Disease Models, Animal</topic><topic>Dysbiosis - complications</topic><topic>Dysbiosis - microbiology</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Polysomnography</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Sleep - physiology</topic><topic>Sleep Apnea Syndromes - complications</topic><topic>Sleep Apnea Syndromes - microbiology</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durgan, David J</creatorcontrib><creatorcontrib>Ganesh, Bhanu P</creatorcontrib><creatorcontrib>Cope, Julia L</creatorcontrib><creatorcontrib>Ajami, Nadim J</creatorcontrib><creatorcontrib>Phillips, Sharon C</creatorcontrib><creatorcontrib>Petrosino, Joseph F</creatorcontrib><creatorcontrib>Hollister, Emily B</creatorcontrib><creatorcontrib>Bryan, Jr, Robert M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durgan, David J</au><au>Ganesh, Bhanu P</au><au>Cope, Julia L</au><au>Ajami, Nadim J</au><au>Phillips, Sharon C</au><au>Petrosino, Joseph F</au><au>Hollister, Emily B</au><au>Bryan, Jr, Robert M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>67</volume><issue>2</issue><spage>469</spage><epage>474</epage><pages>469-474</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><abstract>Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P<0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate (P<0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P<0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.</abstract><cop>United States</cop><pmid>26711739</pmid><doi>10.1161/HYPERTENSIONAHA.115.06672</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2016-02, Vol.67 (2), p.469-474 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4713369 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Blood Pressure - physiology Disease Models, Animal Dysbiosis - complications Dysbiosis - microbiology Gastrointestinal Microbiome - physiology Hypertension - etiology Hypertension - physiopathology Male Polysomnography Rats Rats, Long-Evans Sleep - physiology Sleep Apnea Syndromes - complications Sleep Apnea Syndromes - microbiology Sleep Apnea Syndromes - physiopathology |
| title | Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T03%3A14%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20the%20Gut%20Microbiome%20in%20Obstructive%20Sleep%20Apnea-Induced%20Hypertension&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Durgan,%20David%20J&rft.date=2016-02-01&rft.volume=67&rft.issue=2&rft.spage=469&rft.epage=474&rft.pages=469-474&rft.issn=0194-911X&rft.eissn=1524-4563&rft_id=info:doi/10.1161/HYPERTENSIONAHA.115.06672&rft_dat=%3Cproquest_pubme%3E1760875518%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1760875518&rft_id=info:pmid/26711739&rfr_iscdi=true |