How to make an oligodendrocyte

Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which leads to impaired neurological function in a broad array of diseases ranging from pediatric leukodystrophies and cerebr...

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Veröffentlicht in:	Development (Cambridge) 2015-12, Vol.142 (23), p.3983-3995
Hauptverfasser:	Goldman, Steven A, Kuypers, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Differentiation Cell Transplantation Demyelinating Diseases - metabolism Developmental Biology - methods Humans Induced Pluripotent Stem Cells - cytology Mice Multiple Sclerosis - metabolism Myelin Sheath - physiology Oligodendroglia - cytology Oligodendroglia - physiology Phenotype Pluripotent Stem Cells - cytology Primer Prosencephalon - cytology Spinal Cord - cytology
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