Generation of serotonin neurons from human pluripotent stem cells

Human pluripotent stem cells are efficiently differentiated to serotonin neurons, a cell type associated with various psychiatric disorders. Serotonin neurons located in the raphe nucleus of the hindbrain have crucial roles in regulating brain functions and have been implicated in various psychiatri...

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Veröffentlicht in:	Nature biotechnology 2016-01, Vol.34 (1), p.89-94
Hauptverfasser:	Lu, Jianfeng, Zhong, Xuefei, Liu, Huisheng, Hao, Ling, Huang, Cindy Tzu-Ling, Sherafat, Mohammad Amin, Jones, Jeffrey, Ayala, Melvin, Li, Lingjun, Zhang, Su-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/19 14/63 631/532/1360 631/61/2320 Agriculture Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Brain Cellular biology Drug approval Escitalopram Humans Hydroxylases letter Life Sciences Mental disorders Neurons Neurons - cytology Neurons - metabolism Oxalates Oxalic acid Phenols (Class of compounds) Physiological aspects Pluripotent Stem Cells - cytology Serotonin Serotonin - metabolism Stem cells Time Tryptophan
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