PCSK6-mediated corin activation is essential for normal blood pressure

PCSK6 is identified as the protease that cleaves and activates the zymogen form of corin, a protease that in turn activates the natriuretic peptides that control salt balance and blood pressure. Hypertension is the most common cardiovascular disease, afflicting >30% of adults 1 . The cause of hyp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2015-09, Vol.21 (9), p.1048-1053
Hauptverfasser:	Chen, Shenghan, Cao, Pengxiu, Dong, Ningzheng, Peng, Jianhao, Zhang, Chunyi, Wang, Hao, Zhou, Tiantian, Yang, Junhua, Zhang, Yue, Martelli, Elizabeth E, Naga Prasad, Sathyamangla V, Miller, Rachel E, Malfait, Anne-Marie, Zhou, Yiqing, Wu, Qingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 631/45/468 692/699/75/243 82/1 82/29 82/80 82/83 Animals Biomedicine Blood Pressure Cancer Research Cardiovascular diseases Cricetinae Enzymes HEK293 Cells Humans Hypertension Hypertension - etiology Infectious Diseases letter Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Mutation Natriuretic peptides Neurosciences Peptides Physiological aspects Proprotein Convertases - genetics Proprotein Convertases - physiology Proteases Proteins Serine Endopeptidases - genetics Serine Endopeptidases - physiology Sodium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!