Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations

Background. Advanced penile squamous cell carcinoma (PSCC) is associated with poor survival due to the aggressiveness of the disease and lack of effective systemic therapies. Comprehensive genomic profiling (CGP) was performed to identify clinically relevant genomic alterations (CRGAs). Materials an...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2016-01, Vol.21 (1), p.33-39
Hauptverfasser:	Ali, Siraj M., Pal, Sumanta K., Wang, Kai, Palma, Norma A., Sanford, Eric, Bailey, Mark, He, Jie, Elvin, Julia A., Chmielecki, Juliann, Squillace, Rachel, Dow, Edward, Morosini, Deborah, Buell, Jamie, Yelensky, Roman, Lipson, Doron, Frampton, Garrett M., Howley, Peter, Ross, Jeffrey S., Stephens, Philip J., Miller, Vincent A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Cancer Diagnostics and Molecular Pathology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Class I Phosphatidylinositol 3-Kinases Cyclin-Dependent Kinase Inhibitor p16 - genetics Exons - genetics Gene Expression Profiling Gene Expression Regulation, Neoplastic Genomic profiling High-Throughput Nucleotide Sequencing Human papillomavirus Humans Male Middle Aged Molecular Targeted Therapy Mutation Neoplasm Staging Penile cancer Penile Neoplasms - drug therapy Penile Neoplasms - genetics Penile Neoplasms - pathology Phosphatidylinositol 3-Kinases - genetics Receptor, Epidermal Growth Factor - genetics Receptor, Notch1 - genetics Sequencing Targeted therapy
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