A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study
Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons. The effects of a multinutrient supplement on...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2016-02, Vol.71 (2), p.236-242 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Strike, Siobhán C Carlisle, Alison Gibson, E Leigh Dyall, Simon C |
| description | Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons.
The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis.
Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02).
In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty. |
| doi_str_mv | 10.1093/gerona/glv109 |
| format | Article |
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The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis.
Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02).
In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glv109</identifier><identifier>PMID: 26265727</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Clinical trials ; Cognition & reasoning ; Cognition Disorders - complications ; Cognition Disorders - drug therapy ; Dietary Supplements ; Double-Blind Method ; Fatty acids ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Fish Oils - therapeutic use ; Frail Elderly ; Frailty ; Gait Disorders, Neurologic - drug therapy ; Gait Disorders, Neurologic - etiology ; Humans ; Middle Aged ; Mobility ; Older people ; Pilot Projects ; Plant Oils - therapeutic use ; Treatment Outcome</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2016-02, Vol.71 (2), p.236-242</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America.</rights><rights>Copyright Oxford University Press, UK Feb 2016</rights><rights>The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3f7c592f898df335ee1e14e59fb6d1e95d48362babb212abb45609b3c912b0ae3</citedby><cites>FETCH-LOGICAL-c415t-3f7c592f898df335ee1e14e59fb6d1e95d48362babb212abb45609b3c912b0ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26265727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strike, Siobhán C</creatorcontrib><creatorcontrib>Carlisle, Alison</creatorcontrib><creatorcontrib>Gibson, E Leigh</creatorcontrib><creatorcontrib>Dyall, Simon C</creatorcontrib><title>A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Mobility is a key determinant of frailty in older persons, and a variety of dietary factors, such as the omega-3 fatty acid docosahexaenoic acid (DHA), are positively associated with decreased frailty and improved mobility and cognition in older persons.
The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis.
Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02).
In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Clinical trials</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - complications</subject><subject>Cognition Disorders - drug therapy</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Fish Oils - therapeutic use</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Gait Disorders, Neurologic - drug therapy</subject><subject>Gait Disorders, Neurologic - etiology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mobility</subject><subject>Older people</subject><subject>Pilot Projects</subject><subject>Plant Oils - therapeutic use</subject><subject>Treatment Outcome</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhSNERR-wZIsssWFBqB-xk7CoNEwpRSqaiodgZ9nxTerKsQfHqTT8l_7XejRtBXhh36v7-dhHpyheEvyO4JYdDxCDV8eDu8ntk-KA1LwpOeO_nuYa123JMRb7xeE0XePt4vRZsU8FFbym9UFxu0DndrhCqxEGVTJ0plLaoEVnDfoyu2T9nKIFn9C3eb12MG7LD-Cht2lCyzB4m2zwSPnMB22dzbetRytnIKKfIfPv0QJ9zfMw2j9g3qLTMGsHpXbW5-7SqQ50KLvgUwzOgUGX1oX8XprN5nmx1ys3wYv786j4cfbx-_K8vFh9-rxcXJRdRXgqWV93vKV90zamZ4wDECAV8LbXwhBouakaJqhWWlNC815xgVvNupZQjRWwo-Jkp7ue9Qimyy6jcnId7ajiRgZl5b8Tb6_kEG5kVeNaNE0WeHMvEMPvGaYkRzt14JzyEOZJklrgRtS4whl9_R96Hebos70tVREmGioyVe6oLoZpitA_foZguQ1e7oKXu-Az_-pvB4_0Q9LsDt7PrgE</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Strike, Siobhán C</creator><creator>Carlisle, Alison</creator><creator>Gibson, E Leigh</creator><creator>Dyall, Simon C</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160201</creationdate><title>A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study</title><author>Strike, Siobhán C ; Carlisle, Alison ; Gibson, E Leigh ; Dyall, Simon C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3f7c592f898df335ee1e14e59fb6d1e95d48362babb212abb45609b3c912b0ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Clinical trials</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - complications</topic><topic>Cognition Disorders - drug therapy</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Female</topic><topic>Fish Oils - therapeutic use</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Gait Disorders, Neurologic - drug therapy</topic><topic>Gait Disorders, Neurologic - etiology</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mobility</topic><topic>Older people</topic><topic>Pilot Projects</topic><topic>Plant Oils - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strike, Siobhán C</creatorcontrib><creatorcontrib>Carlisle, Alison</creatorcontrib><creatorcontrib>Gibson, E Leigh</creatorcontrib><creatorcontrib>Dyall, Simon C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. 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The effects of a multinutrient supplement on mobility and cognition were assessed in postmenopausal women (60-84 years). Participants received either Efalex Active 50+ (1g DHA, 160 mg eicosapentaenoic acid, 240 mg Ginkgo biloba, 60 mg phosphatidylserine, 20mg d-α tocopherol, 1mg folic acid, and 20 µg vitamin B12 per day; N = 15) or placebo (N = 12) for 6 months. Mobility was assessed by VICON 9 motion capture camera system synchronized with Kistler force plates, cognitive performance by computerized cognitive function tests, and blood fatty acid levels by pin-prick analysis.
Significant effects of treatment were seen in two of the four cognitive tests, with shorter mean latencies in a motor screening task (p < .05) and more words remembered (p < .03), and one of the three primary mobility measures with improved habitual walking speed (p < .05). Compared with the placebo group, supplementation also resulted in significantly higher blood DHA levels (p < .02).
In this pilot study, multinutrient supplementation improved cognition and mobility in able older females at clinically relevant levels, suggesting a potential role in reducing the decline to frailty.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>26265727</pmid><doi>10.1093/gerona/glv109</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Clinical trials Cognition & reasoning Cognition Disorders - complications Cognition Disorders - drug therapy Dietary Supplements Double-Blind Method Fatty acids Fatty Acids, Omega-3 - therapeutic use Female Fish Oils - therapeutic use Frail Elderly Frailty Gait Disorders, Neurologic - drug therapy Gait Disorders, Neurologic - etiology Humans Middle Aged Mobility Older people Pilot Projects Plant Oils - therapeutic use Treatment Outcome |
| title | A High Omega-3 Fatty Acid Multinutrient Supplement Benefits Cognition and Mobility in Older Women: A Randomized, Double-blind, Placebo-controlled Pilot Study |
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