Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins

A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19063-19063, Article 19063
Hauptverfasser:	Batra, Jyoti, Tripathi, Shashank, Kumar, Amrita, Katz, Jacqueline M., Cox, Nancy J., Lal, Renu B., Sambhara, Suryaprakash, Lal, Sunil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/31 13/89 14 14/1 14/19 14/32 631/326/596/1578 631/45/56 82 82/80 Benzhydryl Compounds - pharmacology Cell Line Cell Nucleus - metabolism Gene Knockdown Techniques Genomes Heat shock proteins Host-Pathogen Interactions HSP40 Heat-Shock Proteins - antagonists & inhibitors HSP40 Heat-Shock Proteins - chemistry HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Hsp40 protein Humanities and Social Sciences Humans Influenza Influenza A Influenza A virus - metabolism Influenza A virus - physiology Influenza, Human - metabolism Influenza, Human - virology Life cycles Localization Models, Biological multidisciplinary Nuclear transport Protein Binding Protein Interaction Domains and Motifs Protein Transport Pyrrolidinones - pharmacology Replication Ribonucleoproteins Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism RNA, Small Interfering - genetics RNA-mediated interference Science Translocation Viral Proteins - chemistry Viral Proteins - metabolism Virus Replication
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