Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins
A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear...
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| Veröffentlicht in: | Scientific reports 2016-01, Vol.6 (1), p.19063-19063, Article 19063 |
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| description | A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localization signals. Here, we demonstrate that cellular heat shock protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins (vRNPs) and is important for efficient IAV replication. Hsp40 was found to interact with NP component of IAV RNPs during early stages of infection. This interaction is mediated by the J domain of Hsp40 and N-terminal region of NP. Drug or RNAi mediated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase function and attenuates overall viral replication. Hsp40 was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation. These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins. |
| doi_str_mv | 10.1038/srep19063 |
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The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localization signals. Here, we demonstrate that cellular heat shock protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins (vRNPs) and is important for efficient IAV replication. Hsp40 was found to interact with NP component of IAV RNPs during early stages of infection. This interaction is mediated by the J domain of Hsp40 and N-terminal region of NP. Drug or RNAi mediated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase function and attenuates overall viral replication. Hsp40 was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation. These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep19063</identifier><identifier>PMID: 26750153</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/106 ; 13/109 ; 13/31 ; 13/89 ; 14 ; 14/1 ; 14/19 ; 14/32 ; 631/326/596/1578 ; 631/45/56 ; 82 ; 82/80 ; Benzhydryl Compounds - pharmacology ; Cell Line ; Cell Nucleus - metabolism ; Gene Knockdown Techniques ; Genomes ; Heat shock proteins ; Host-Pathogen Interactions ; HSP40 Heat-Shock Proteins - antagonists & inhibitors ; HSP40 Heat-Shock Proteins - chemistry ; HSP40 Heat-Shock Proteins - genetics ; HSP40 Heat-Shock Proteins - metabolism ; Hsp40 protein ; Humanities and Social Sciences ; Humans ; Influenza ; Influenza A ; Influenza A virus - metabolism ; Influenza A virus - physiology ; Influenza, Human - metabolism ; Influenza, Human - virology ; Life cycles ; Localization ; Models, Biological ; multidisciplinary ; Nuclear transport ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Transport ; Pyrrolidinones - pharmacology ; Replication ; Ribonucleoproteins ; Ribonucleoproteins - chemistry ; Ribonucleoproteins - metabolism ; RNA, Small Interfering - genetics ; RNA-mediated interference ; Science ; Translocation ; Viral Proteins - chemistry ; Viral Proteins - metabolism ; Virus Replication</subject><ispartof>Scientific reports, 2016-01, Vol.6 (1), p.19063-19063, Article 19063</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Jan 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-47cd924cd083df77780e43821d044f35a9203a4e8c5ae2fb18062abbffd8ca1d3</citedby><cites>FETCH-LOGICAL-c504t-47cd924cd083df77780e43821d044f35a9203a4e8c5ae2fb18062abbffd8ca1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707480/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707480/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26750153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batra, Jyoti</creatorcontrib><creatorcontrib>Tripathi, Shashank</creatorcontrib><creatorcontrib>Kumar, Amrita</creatorcontrib><creatorcontrib>Katz, Jacqueline M.</creatorcontrib><creatorcontrib>Cox, Nancy J.</creatorcontrib><creatorcontrib>Lal, Renu B.</creatorcontrib><creatorcontrib>Sambhara, Suryaprakash</creatorcontrib><creatorcontrib>Lal, Sunil K.</creatorcontrib><title>Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localization signals. Here, we demonstrate that cellular heat shock protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins (vRNPs) and is important for efficient IAV replication. Hsp40 was found to interact with NP component of IAV RNPs during early stages of infection. This interaction is mediated by the J domain of Hsp40 and N-terminal region of NP. Drug or RNAi mediated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase function and attenuates overall viral replication. Hsp40 was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation. These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins.</description><subject>13</subject><subject>13/106</subject><subject>13/109</subject><subject>13/31</subject><subject>13/89</subject><subject>14</subject><subject>14/1</subject><subject>14/19</subject><subject>14/32</subject><subject>631/326/596/1578</subject><subject>631/45/56</subject><subject>82</subject><subject>82/80</subject><subject>Benzhydryl Compounds - pharmacology</subject><subject>Cell Line</subject><subject>Cell Nucleus - metabolism</subject><subject>Gene Knockdown Techniques</subject><subject>Genomes</subject><subject>Heat shock proteins</subject><subject>Host-Pathogen Interactions</subject><subject>HSP40 Heat-Shock Proteins - antagonists & inhibitors</subject><subject>HSP40 Heat-Shock Proteins - chemistry</subject><subject>HSP40 Heat-Shock Proteins - genetics</subject><subject>HSP40 Heat-Shock Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batra, Jyoti</au><au>Tripathi, Shashank</au><au>Kumar, Amrita</au><au>Katz, Jacqueline M.</au><au>Cox, Nancy J.</au><au>Lal, Renu B.</au><au>Sambhara, Suryaprakash</au><au>Lal, Sunil K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-01-11</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>19063</spage><epage>19063</epage><pages>19063-19063</pages><artnum>19063</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing virus infection. IAV nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localization signals. Here, we demonstrate that cellular heat shock protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins (vRNPs) and is important for efficient IAV replication. Hsp40 was found to interact with NP component of IAV RNPs during early stages of infection. This interaction is mediated by the J domain of Hsp40 and N-terminal region of NP. Drug or RNAi mediated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase function and attenuates overall viral replication. Hsp40 was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation. These studies demonstrate an important role for cellular chaperone Hsp40/DnaJB1 in influenza A virus life cycle by assisting nuclear trafficking of viral ribonucleoproteins.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26750153</pmid><doi>10.1038/srep19063</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13 13/106 13/109 13/31 13/89 14 14/1 14/19 14/32 631/326/596/1578 631/45/56 82 82/80 Benzhydryl Compounds - pharmacology Cell Line Cell Nucleus - metabolism Gene Knockdown Techniques Genomes Heat shock proteins Host-Pathogen Interactions HSP40 Heat-Shock Proteins - antagonists & inhibitors HSP40 Heat-Shock Proteins - chemistry HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Hsp40 protein Humanities and Social Sciences Humans Influenza Influenza A Influenza A virus - metabolism Influenza A virus - physiology Influenza, Human - metabolism Influenza, Human - virology Life cycles Localization Models, Biological multidisciplinary Nuclear transport Protein Binding Protein Interaction Domains and Motifs Protein Transport Pyrrolidinones - pharmacology Replication Ribonucleoproteins Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism RNA, Small Interfering - genetics RNA-mediated interference Science Translocation Viral Proteins - chemistry Viral Proteins - metabolism Virus Replication |
| title | Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins |
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