The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97

Valosin-containing protein/p97 is an ATP-driven protein segregase that cooperates with distinct protein cofactors to control various aspects of cellular homeostasis. Mutations at the interface between the regulatory N-domain and the first of two ATPase domains (D1 and D2) deregulate the ATPase activ...

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Veröffentlicht in:	The Journal of biological chemistry 2015-12, Vol.290 (49), p.29414-29427
Hauptverfasser:	Trusch, Franziska, Matena, Anja, Vuk, Maja, Koerver, Lisa, Knævelsrud, Helene, Freemont, Paul S., Meyer, Hemmo, Bayer, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Adenosine Triphosphatases - metabolism Amino Acid Motifs ATPase Autophagy-Related Proteins Binding Sites Carrier Proteins - chemistry Carrier Proteins - metabolism Caveolin 1 - metabolism Cell Cycle Proteins - metabolism Cell Line Circular Dichroism endosome Endosomes - metabolism Epitopes - chemistry Fluorescence Polarization Green Fluorescent Proteins - metabolism Homeostasis Humans Lysosomes - metabolism Magnetic Resonance Spectroscopy Mutation nuclear magnetic resonance (NMR) Nuclear Proteins - metabolism p97 Protein Binding protein structure Protein Structure and Folding Protein Structure, Tertiary protein-protein interaction Ubiquitin - chemistry UBXD1 Valosin Containing Protein
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