E5501: phase II study of topotecan sequenced with etoposide/cisplatin, and irinotecan/cisplatin sequenced with etoposide for extensive-stage small-cell lung cancer

Purpose Sequence-dependent improved efficacy of topoisomerase I followed by topoisomerase 2 inhibitors was assessed in a randomized phase II study in extensive-stage small-cell lung cancer (SCLC). Methods Patients with previously untreated extensive-stage SCLC with measurable disease, ECOG performan...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2014-01, Vol.73 (1), p.171-180
Hauptverfasser:	Owonikoko, Taofeek K., Aisner, Joseph, Wang, Xin Victoria, Dahlberg, Suzanne E., Rubin, Eric H., Ramalingam, Suresh S., Gounder, Murugesan, Rausch, Paul Gregory, Axelrod, Rita S., Schiller, Joan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Camptothecin - administration & dosage Camptothecin - analogs & derivatives Cancer Research Cisplatin - administration & dosage Etoposide - administration & dosage Female Humans Irinotecan Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Pneumology Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - mortality Small Cell Lung Carcinoma - pathology Topoisomerase I Inhibitors - administration & dosage Topoisomerase II Inhibitors - administration & dosage Topotecan - administration & dosage Tumors Tumors of the respiratory system and mediastinum
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