Characterization of a cAMP responsive transcription factor, Cmr (Rv1675c), in TB complex mycobacteria reveals overlap with the DosR (DevR) dormancy regulon

Mycobacterium tuberculosis (Mtb) Cmr (Rv1675c) is a CRP/FNR family transcription factor known to be responsive to cAMP levels and during macrophage infections. However, Cmr's DNA binding properties, cellular targets and overall role in tuberculosis (TB) complex bacteria have not been characteri...

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Veröffentlicht in:	Nucleic acids research 2016-01, Vol.44 (1), p.134-151
Hauptverfasser:	Ranganathan, Sridevi, Bai, Guangchun, Lyubetskaya, Anna, Knapp, Gwendowlyn S, Peterson, Matthew W, Gazdik, Michaela, C Gomes, Antonio L, Galagan, James E, McDonough, Kathleen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Cattle Chromatin Immunoprecipitation Cyclic AMP - metabolism DNA - metabolism Gene Expression Regulation, Bacterial Gene Knockout Techniques Gene regulation, Chromatin and Epigenetics Humans Mycobacterium bovis - genetics Mycobacterium bovis - metabolism Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Position-Specific Scoring Matrices Protein Binding Protein Interaction Domains and Motifs Protein Kinases - metabolism Protein Multimerization Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism SELEX Aptamer Technique Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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