Enhanced engraftment, proliferation and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes

Human pluripotent stem cell-derived cardiomyocytes (CMs) are a promising tool for cardiac cell therapy. Although transplantation of induced pluripotent stem cell (iPSC)-derived CMs have been reported in several animal models, the treatment effect was limited, probably due to poor optimization of the...

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Veröffentlicht in:	Scientific reports 2016-01, Vol.6 (1), p.19111-19111, Article 19111
Hauptverfasser:	Funakoshi, Shunsuke, Miki, Kenji, Takaki, Tadashi, Okubo, Chikako, Hatani, Takeshi, Chonabayashi, Kazuhisa, Nishikawa, Misato, Takei, Ikue, Oishi, Akiko, Narita, Megumi, Hoshijima, Masahiko, Kimura, Takeshi, Yamanaka, Shinya, Yoshida, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	59/5 631/532/2064/2158 692/308/2171 Animal models Animals Bioluminescence Biomarkers - metabolism Cardiomyocytes Cell Differentiation Cell Proliferation Cell Tracking Cell- and Tissue-Based Therapy - methods Echocardiography Gene Expression Graft Survival Heart diseases Heart transplantation Humanities and Social Sciences Humans Immunodeficiency Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - physiology Ki-67 Antigen - genetics Ki-67 Antigen - immunology Male Mice Mice, Inbred NOD multidisciplinary Myocardial Infarction - immunology Myocardial Infarction - pathology Myocardial Infarction - therapy Myocytes, Cardiac - cytology Myocytes, Cardiac - physiology Myocytes, Cardiac - transplantation Optical Imaging Pluripotency Rodents Science Stem cells Transplantation
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