Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2)

Carcinoembryonic antigen-related cell adhesion molecule 2 (CEACAM2) regulates food intake as demonstrated by hyperphagia in mice with the Ceacam2 null mutation (Cc2−/−). This study investigated whether CEACAM2 also regulates insulin secretion. Ceacam2 deletion caused an increase in β-cell secretory...

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Veröffentlicht in:	The Journal of biological chemistry 2016-01, Vol.291 (2), p.980-988
Hauptverfasser:	Ghanem, Simona S., Heinrich, Garrett, Lester, Sumona G., Pfeiffer, Verena, Bhattacharya, Sumit, Patel, Payal R., DeAngelis, Anthony M., Dai, Tong, Ramakrishnan, Sadeesh K., Smiley, Zachary N., Jung, Dae Y., Lee, Yongjin, Kitamura, Tadahiro, Ergun, Suleyman, Kulkarni, Rohit N., Kim, Jason K., Giovannucci, David R., Najjar, Sonia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Calcium Channels, L-Type - metabolism CEACAM2 Cell Adhesion Molecules - deficiency Cell Adhesion Molecules - metabolism diabetes enteroendocrine cells Fluorescent Antibody Technique gene knock-out GLP-1 Glucagon-Like Peptide 1 - metabolism Glucose - pharmacology Glucose Tolerance Test Insulin - metabolism insulin clearance insulin resistance Insulin Secretion intestine Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Metabolism Mice Wakefulness
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