Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure
We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were...
Gespeichert in:
| Veröffentlicht in: | Thorax 1976-12, Vol.31 (6), p.730-735 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 735 |
|---|---|
| container_issue | 6 |
| container_start_page | 730 |
| container_title | Thorax |
| container_volume | 31 |
| creator | Leitch, A G Clancy, L J Leggett, R J Tweeddale, P Dawson, P Evans, J I |
| description | We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact hypoxic drive to breathing, developed marked hypercapnia and acidosis when his PO2 was restored to normal during sleep; the other, who had no hypoxic drive to breathing, developed no more hypercapnia or acidosis during sleep when breathing oxygen than when breathing air. Oxygen therapy may improve sleep disturbance in these patients, but its effect on the drive to breathing during sleep should be considered if severe hypercapnia and acidosis are to be avoided. |
| doi_str_mv | 10.1136/thx.31.6.730 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_470503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83713900</sourcerecordid><originalsourceid>FETCH-LOGICAL-b436t-5ecc6d86accf9deccf7c79cb0f35477935092f829ce24da6c1c1efd6c60a90623</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhS1EBdvCjRsXS0hw2Sx2nNjJoYeqolCpEhc4W44zSbxy7GA7hT3w33G1FdAeehrNvG9Gb_QQekPJjlLGP6bp147RHd8JRp6hDa14U7Cy5c_RhpCKFJwJ_hKdxrgnhDSUihfohLKa0g36fRESBKMs7qz3PR5VxAlcNN7FLZ4OffAjOJzbLVaux2BBp-DBaVgmZf0Y1Iz7NRg34mgBFmwcXlQy4FLEP02asJ6Cd0bj2zwyViUfDnhQxq4BXqGTQdkIr-_rGfp-9enb5Zfi5uvn68uLm6KrGE9FDVrzvuFK66HtczMILVrdkYHVlRAtq0lbDk3ZaiirXnFNNYWh55oT1RJesjN0fry7rN0Mvc5OgrJyCWZW4SC9MvKh4swkR38rK0FqwvL--_v94H-sEJOcTdRgrXLg1ygbJihrCcngu0fg3q_B5d8kFYKWDee0ydT2SOngYwww_HVCibxLVOZEJaOSy5xoxt_-7_4ffBdhVj8c1W7eP33nD62VrVo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1771286618</pqid></control><display><type>article</type><title>Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Leitch, A G ; Clancy, L J ; Leggett, R J ; Tweeddale, P ; Dawson, P ; Evans, J I</creator><creatorcontrib>Leitch, A G ; Clancy, L J ; Leggett, R J ; Tweeddale, P ; Dawson, P ; Evans, J I</creatorcontrib><description>We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact hypoxic drive to breathing, developed marked hypercapnia and acidosis when his PO2 was restored to normal during sleep; the other, who had no hypoxic drive to breathing, developed no more hypercapnia or acidosis during sleep when breathing oxygen than when breathing air. Oxygen therapy may improve sleep disturbance in these patients, but its effect on the drive to breathing during sleep should be considered if severe hypercapnia and acidosis are to be avoided.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.31.6.730</identifier><identifier>PMID: 13511</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Carbon Dioxide - blood ; Electroencephalography ; Female ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Oxygen - blood ; Oxygen Inhalation Therapy ; Partial Pressure ; Respiratory Insufficiency - blood ; Respiratory Insufficiency - physiopathology ; Respiratory Insufficiency - therapy ; Sleep</subject><ispartof>Thorax, 1976-12, Vol.31 (6), p.730-735</ispartof><rights>Copyright BMJ Publishing Group LTD Dec 1976</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b436t-5ecc6d86accf9deccf7c79cb0f35477935092f829ce24da6c1c1efd6c60a90623</citedby><cites>FETCH-LOGICAL-b436t-5ecc6d86accf9deccf7c79cb0f35477935092f829ce24da6c1c1efd6c60a90623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC470503/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC470503/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leitch, A G</creatorcontrib><creatorcontrib>Clancy, L J</creatorcontrib><creatorcontrib>Leggett, R J</creatorcontrib><creatorcontrib>Tweeddale, P</creatorcontrib><creatorcontrib>Dawson, P</creatorcontrib><creatorcontrib>Evans, J I</creatorcontrib><title>Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure</title><title>Thorax</title><addtitle>Thorax</addtitle><description>We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact hypoxic drive to breathing, developed marked hypercapnia and acidosis when his PO2 was restored to normal during sleep; the other, who had no hypoxic drive to breathing, developed no more hypercapnia or acidosis during sleep when breathing oxygen than when breathing air. Oxygen therapy may improve sleep disturbance in these patients, but its effect on the drive to breathing during sleep should be considered if severe hypercapnia and acidosis are to be avoided.</description><subject>Carbon Dioxide - blood</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen - blood</subject><subject>Oxygen Inhalation Therapy</subject><subject>Partial Pressure</subject><subject>Respiratory Insufficiency - blood</subject><subject>Respiratory Insufficiency - physiopathology</subject><subject>Respiratory Insufficiency - therapy</subject><subject>Sleep</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFv1DAQhS1EBdvCjRsXS0hw2Sx2nNjJoYeqolCpEhc4W44zSbxy7GA7hT3w33G1FdAeehrNvG9Gb_QQekPJjlLGP6bp147RHd8JRp6hDa14U7Cy5c_RhpCKFJwJ_hKdxrgnhDSUihfohLKa0g36fRESBKMs7qz3PR5VxAlcNN7FLZ4OffAjOJzbLVaux2BBp-DBaVgmZf0Y1Iz7NRg34mgBFmwcXlQy4FLEP02asJ6Cd0bj2zwyViUfDnhQxq4BXqGTQdkIr-_rGfp-9enb5Zfi5uvn68uLm6KrGE9FDVrzvuFK66HtczMILVrdkYHVlRAtq0lbDk3ZaiirXnFNNYWh55oT1RJesjN0fry7rN0Mvc5OgrJyCWZW4SC9MvKh4swkR38rK0FqwvL--_v94H-sEJOcTdRgrXLg1ygbJihrCcngu0fg3q_B5d8kFYKWDee0ydT2SOngYwww_HVCibxLVOZEJaOSy5xoxt_-7_4ffBdhVj8c1W7eP33nD62VrVo</recordid><startdate>19761201</startdate><enddate>19761201</enddate><creator>Leitch, A G</creator><creator>Clancy, L J</creator><creator>Leggett, R J</creator><creator>Tweeddale, P</creator><creator>Dawson, P</creator><creator>Evans, J I</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19761201</creationdate><title>Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure</title><author>Leitch, A G ; Clancy, L J ; Leggett, R J ; Tweeddale, P ; Dawson, P ; Evans, J I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b436t-5ecc6d86accf9deccf7c79cb0f35477935092f829ce24da6c1c1efd6c60a90623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Carbon Dioxide - blood</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen - blood</topic><topic>Oxygen Inhalation Therapy</topic><topic>Partial Pressure</topic><topic>Respiratory Insufficiency - blood</topic><topic>Respiratory Insufficiency - physiopathology</topic><topic>Respiratory Insufficiency - therapy</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leitch, A G</creatorcontrib><creatorcontrib>Clancy, L J</creatorcontrib><creatorcontrib>Leggett, R J</creatorcontrib><creatorcontrib>Tweeddale, P</creatorcontrib><creatorcontrib>Dawson, P</creatorcontrib><creatorcontrib>Evans, J I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leitch, A G</au><au>Clancy, L J</au><au>Leggett, R J</au><au>Tweeddale, P</au><au>Dawson, P</au><au>Evans, J I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1976-12-01</date><risdate>1976</risdate><volume>31</volume><issue>6</issue><spage>730</spage><epage>735</epage><pages>730-735</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact hypoxic drive to breathing, developed marked hypercapnia and acidosis when his PO2 was restored to normal during sleep; the other, who had no hypoxic drive to breathing, developed no more hypercapnia or acidosis during sleep when breathing oxygen than when breathing air. Oxygen therapy may improve sleep disturbance in these patients, but its effect on the drive to breathing during sleep should be considered if severe hypercapnia and acidosis are to be avoided.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>13511</pmid><doi>10.1136/thx.31.6.730</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0040-6376 |
| ispartof | Thorax, 1976-12, Vol.31 (6), p.730-735 |
| issn | 0040-6376 1468-3296 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_470503 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Carbon Dioxide - blood Electroencephalography Female Humans Hydrogen-Ion Concentration Male Middle Aged Oxygen - blood Oxygen Inhalation Therapy Partial Pressure Respiratory Insufficiency - blood Respiratory Insufficiency - physiopathology Respiratory Insufficiency - therapy Sleep |
| title | Arterial blood gas tensions, hydrogen ion, and electroencephalogram during sleep in patients with chronic ventilatory failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T03%3A43%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Arterial%20blood%20gas%20tensions,%20hydrogen%20ion,%20and%20electroencephalogram%20during%20sleep%20in%20patients%20with%20chronic%20ventilatory%20failure&rft.jtitle=Thorax&rft.au=Leitch,%20A%20G&rft.date=1976-12-01&rft.volume=31&rft.issue=6&rft.spage=730&rft.epage=735&rft.pages=730-735&rft.issn=0040-6376&rft.eissn=1468-3296&rft.coden=THORA7&rft_id=info:doi/10.1136/thx.31.6.730&rft_dat=%3Cproquest_pubme%3E83713900%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1771286618&rft_id=info:pmid/13511&rfr_iscdi=true |